Mechanistic Middle-Out Physiologically Based Toxicokinetic Modeling of Transporter-Dependent Disposition of Perfluorooctanoic Acid in Humans

[Image: see text] Perfluorooctanoic acid (PFOA) is an environmental toxicant exhibiting a years-long biological half-life (t(1/2)) in humans and is linked with adverse health effects. However, limited understanding of its toxicokinetics (TK) has obstructed the necessary risk assessment. Here, we con...

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Autores principales: Lin, Jieying, Chin, Sheng Yuan, Tan, Shawn Pei Feng, Koh, Hor Cheng, Cheong, Eleanor Jing Yi, Chan, Eric Chun Yong, Chan, James Chun Yip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10157889/
https://www.ncbi.nlm.nih.gov/pubmed/37072124
http://dx.doi.org/10.1021/acs.est.2c05642

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