Lysine Deacetylase Substrate Selectivity: Distinct Interaction Surfaces Drive Positive and Negative Selection for Residues Following Acetyllysine

[Image: see text] Lysine acetylation is a post-translational modification that is reversed by lysine deacetylases (KDACs). The goal of this work was to identify determinants of substrate specificity for KDACs, focusing on short-range interactions occurring with residues immediately following the ace...

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Detalles Bibliográficos
Autores principales: Toro, Tasha B., Bornes, Kiara E., Watt, Terry J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10157890/
https://www.ncbi.nlm.nih.gov/pubmed/37043688
http://dx.doi.org/10.1021/acs.biochem.3c00001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10157890/
https://www.ncbi.nlm.nih.gov/pubmed/37043688
http://dx.doi.org/10.1021/acs.biochem.3c00001

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