Functional characterization of age-dependent p16 epimutation reveals biological drivers and therapeutic targets for colorectal cancer

BACKGROUND: Methylation of the p16 promoter resulting in epigenetic gene silencing—known as p16 epimutation—is frequently found in human colorectal cancer and is also common in normal-appearing colonic mucosa of aging individuals. Thus, to improve clinical care of colorectal cancer (CRC) patients, w...

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Detalles Bibliográficos
Autores principales: Yang, Li, Chen, Xiaomin, Lee, Christy, Shi, Jiejun, Lawrence, Emily B., Zhang, Lanjing, Li, Yumei, Gao, Nan, Jung, Sung Yun, Creighton, Chad J., Li, Jingyi Jessica, Cui, Ya, Arimura, Sumimasa, Lei, Yunping, Li, Wei, Shen, Lanlan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10157929/
https://www.ncbi.nlm.nih.gov/pubmed/37143122
http://dx.doi.org/10.1186/s13046-023-02689-y

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