Pan-cancer analysis revealed H3K4me1 at bivalent promoters premarks DNA hypermethylation during tumor development and identified the regulatory role of DNA methylation in relation to histone modifications

BACKGROUND: DNA hypermethylation at promoter CpG islands (CGIs) is a hallmark of cancers and could lead to dysregulation of gene expression in the development of cancers, however, its dynamics and regulatory mechanisms remain elusive. Bivalent genes, that direct development and differentiation of st...

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Detalles Bibliográficos
Autores principales: Lu, Yang, Cao, Qiang, Yu, Yue, Sun, Yazhou, Jiang, Xuan, Li, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10157937/
https://www.ncbi.nlm.nih.gov/pubmed/37138231
http://dx.doi.org/10.1186/s12864-023-09341-1

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