Ketogenic Diet and Drug-Induced Hepatotoxicity During Tuberculosis Treatment

When therapy with hepatotoxic drugs is being considered, all other possible contributing agents of liver damage should be held to account. While not generally considered a risk factor, we present 2 cases in which ketogenic diet (KD) may have played a role in liver injury due to antituberculosis drug...

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Autores principales: Branco Caetano, Francisco, Milheiro Silva, Tiago, Gonçalves, Cristina, Dias, Ana Isabel, Brito, Maria João
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins, Inc. 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10158376/
https://www.ncbi.nlm.nih.gov/pubmed/37168635
http://dx.doi.org/10.1097/PG9.0000000000000216
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author Branco Caetano, Francisco
Milheiro Silva, Tiago
Gonçalves, Cristina
Dias, Ana Isabel
Brito, Maria João
author_facet Branco Caetano, Francisco
Milheiro Silva, Tiago
Gonçalves, Cristina
Dias, Ana Isabel
Brito, Maria João
author_sort Branco Caetano, Francisco
collection PubMed
description When therapy with hepatotoxic drugs is being considered, all other possible contributing agents of liver damage should be held to account. While not generally considered a risk factor, we present 2 cases in which ketogenic diet (KD) may have played a role in liver injury due to antituberculosis drugs. Ketogenic diet has been linked to liver injury, and while its pathophysiology remains obscure, carnitine depletion could play a role, as it is a mechanism of liver damage common to KD and antituberculosis drug regimens.
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spelling pubmed-101583762023-05-09 Ketogenic Diet and Drug-Induced Hepatotoxicity During Tuberculosis Treatment Branco Caetano, Francisco Milheiro Silva, Tiago Gonçalves, Cristina Dias, Ana Isabel Brito, Maria João JPGN Rep Case Report When therapy with hepatotoxic drugs is being considered, all other possible contributing agents of liver damage should be held to account. While not generally considered a risk factor, we present 2 cases in which ketogenic diet (KD) may have played a role in liver injury due to antituberculosis drugs. Ketogenic diet has been linked to liver injury, and while its pathophysiology remains obscure, carnitine depletion could play a role, as it is a mechanism of liver damage common to KD and antituberculosis drug regimens. Lippincott Williams & Wilkins, Inc. 2022-06-21 /pmc/articles/PMC10158376/ /pubmed/37168635 http://dx.doi.org/10.1097/PG9.0000000000000216 Text en Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Case Report
Branco Caetano, Francisco
Milheiro Silva, Tiago
Gonçalves, Cristina
Dias, Ana Isabel
Brito, Maria João
Ketogenic Diet and Drug-Induced Hepatotoxicity During Tuberculosis Treatment
title Ketogenic Diet and Drug-Induced Hepatotoxicity During Tuberculosis Treatment
title_full Ketogenic Diet and Drug-Induced Hepatotoxicity During Tuberculosis Treatment
title_fullStr Ketogenic Diet and Drug-Induced Hepatotoxicity During Tuberculosis Treatment
title_full_unstemmed Ketogenic Diet and Drug-Induced Hepatotoxicity During Tuberculosis Treatment
title_short Ketogenic Diet and Drug-Induced Hepatotoxicity During Tuberculosis Treatment
title_sort ketogenic diet and drug-induced hepatotoxicity during tuberculosis treatment
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10158376/
https://www.ncbi.nlm.nih.gov/pubmed/37168635
http://dx.doi.org/10.1097/PG9.0000000000000216
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