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The Resolution of Severe Iron-Deficiency Anemia After Successful Eradication of Helicobacter pylori in Teenagers

Long-term follow-up studies with Helicobacter pylori eradication therapy in children with H. pylori-associated iron-deficiency anemia (IDA) are scarce. We investigated whether successful H. pylori eradication would result in maintaining resolution of recurrent and/or refractory IDA in a cohort of te...

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Autores principales: Kato, Seiichi, Gold, Benjamin D., Kato, Ayumu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins, Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10158392/
https://www.ncbi.nlm.nih.gov/pubmed/37168639
http://dx.doi.org/10.1097/PG9.0000000000000238
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author Kato, Seiichi
Gold, Benjamin D.
Kato, Ayumu
author_facet Kato, Seiichi
Gold, Benjamin D.
Kato, Ayumu
author_sort Kato, Seiichi
collection PubMed
description Long-term follow-up studies with Helicobacter pylori eradication therapy in children with H. pylori-associated iron-deficiency anemia (IDA) are scarce. We investigated whether successful H. pylori eradication would result in maintaining resolution of recurrent and/or refractory IDA in a cohort of teenagers in Japan. METHODS: In this case series, 7 H. pylori-infected patients with recurrent and/or refractory IDA (12–16 y old) received successful eradication therapy and were then followed for a median of 20 months (range, 9–76 mo) after oral iron supplementation therapy (1–4 mo) was discontinued. Five patients of our study cohort participated in rigorous sports activities. RESULTS: No visual appearance of ulcerations or erosions was found by esophagogastroduodenoscopy. In all patients studied, the gastric biopsies showed histological evidence of chronic gastritis without significant atrophy and intestinal metaplasia. Compared with the baseline (median values: hemoglobin, 6.3 g/dL; serum iron, 9 μg/dL; serum ferritin, 1.5 ng/mL), values of hemoglobin (P < 0.001), serum iron (P < 0.005), and ferritin (P < 0.001) significantly increased, on average, 2–3 months after eradication therapy and these iron indices were maintained at the same or higher levels at the endpoint of follow-up (median values: 14.2 g/dL, 102 μg/dL, and 29.3 ng/mL, respectively). No patient had recurrence of IDA at the time of final follow-up. CONCLUSIONS: H. pylori infection can be closely associated with recurrent or refractory IDA in teenage children. It is speculated that increased iron demands as a result of growth spurt in adolescents may play a synergistic role in combination with H. pylori in the pathogenesis of IDA.
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spelling pubmed-101583922023-05-09 The Resolution of Severe Iron-Deficiency Anemia After Successful Eradication of Helicobacter pylori in Teenagers Kato, Seiichi Gold, Benjamin D. Kato, Ayumu JPGN Rep Original Article Long-term follow-up studies with Helicobacter pylori eradication therapy in children with H. pylori-associated iron-deficiency anemia (IDA) are scarce. We investigated whether successful H. pylori eradication would result in maintaining resolution of recurrent and/or refractory IDA in a cohort of teenagers in Japan. METHODS: In this case series, 7 H. pylori-infected patients with recurrent and/or refractory IDA (12–16 y old) received successful eradication therapy and were then followed for a median of 20 months (range, 9–76 mo) after oral iron supplementation therapy (1–4 mo) was discontinued. Five patients of our study cohort participated in rigorous sports activities. RESULTS: No visual appearance of ulcerations or erosions was found by esophagogastroduodenoscopy. In all patients studied, the gastric biopsies showed histological evidence of chronic gastritis without significant atrophy and intestinal metaplasia. Compared with the baseline (median values: hemoglobin, 6.3 g/dL; serum iron, 9 μg/dL; serum ferritin, 1.5 ng/mL), values of hemoglobin (P < 0.001), serum iron (P < 0.005), and ferritin (P < 0.001) significantly increased, on average, 2–3 months after eradication therapy and these iron indices were maintained at the same or higher levels at the endpoint of follow-up (median values: 14.2 g/dL, 102 μg/dL, and 29.3 ng/mL, respectively). No patient had recurrence of IDA at the time of final follow-up. CONCLUSIONS: H. pylori infection can be closely associated with recurrent or refractory IDA in teenage children. It is speculated that increased iron demands as a result of growth spurt in adolescents may play a synergistic role in combination with H. pylori in the pathogenesis of IDA. Lippincott Williams & Wilkins, Inc. 2022-08-16 /pmc/articles/PMC10158392/ /pubmed/37168639 http://dx.doi.org/10.1097/PG9.0000000000000238 Text en Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kato, Seiichi
Gold, Benjamin D.
Kato, Ayumu
The Resolution of Severe Iron-Deficiency Anemia After Successful Eradication of Helicobacter pylori in Teenagers
title The Resolution of Severe Iron-Deficiency Anemia After Successful Eradication of Helicobacter pylori in Teenagers
title_full The Resolution of Severe Iron-Deficiency Anemia After Successful Eradication of Helicobacter pylori in Teenagers
title_fullStr The Resolution of Severe Iron-Deficiency Anemia After Successful Eradication of Helicobacter pylori in Teenagers
title_full_unstemmed The Resolution of Severe Iron-Deficiency Anemia After Successful Eradication of Helicobacter pylori in Teenagers
title_short The Resolution of Severe Iron-Deficiency Anemia After Successful Eradication of Helicobacter pylori in Teenagers
title_sort resolution of severe iron-deficiency anemia after successful eradication of helicobacter pylori in teenagers
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10158392/
https://www.ncbi.nlm.nih.gov/pubmed/37168639
http://dx.doi.org/10.1097/PG9.0000000000000238
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