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Cardiorenal syndrome in the pediatric population: A systematic review
The concept of cardiorenal syndrome (CRS) is derived from the crosstalk between the heart and kidneys in pathological conditions. Despite the rising importance of CRS, there is a paucity of information on the understanding of its pathophysiology and management, increasing both morbidity and mortalit...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10158476/ https://www.ncbi.nlm.nih.gov/pubmed/37152514 http://dx.doi.org/10.4103/apc.apc_50_22 |
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author | Pradhan, Subal Kumar Adnani, Harsha Safadi, Rama Yerigeri, Keval Nayak, Snehamayee Raina, Rupesh Sinha, Rajiv |
author_facet | Pradhan, Subal Kumar Adnani, Harsha Safadi, Rama Yerigeri, Keval Nayak, Snehamayee Raina, Rupesh Sinha, Rajiv |
author_sort | Pradhan, Subal Kumar |
collection | PubMed |
description | The concept of cardiorenal syndrome (CRS) is derived from the crosstalk between the heart and kidneys in pathological conditions. Despite the rising importance of CRS, there is a paucity of information on the understanding of its pathophysiology and management, increasing both morbidity and mortality for patients. This review summarizes the existing conceptual pathophysiology of different types of CRS and delves into the associated therapeutic modalities with a focus on pediatric cases. Prospective or retrospective observational studies, comparative studies, case reports, case–control, and cross-sectional studies that include pediatric patients with CRS were included in this review. Literature was searched using PubMed, EMBASE, and Google Scholar with keywords including “cardio-renal syndrome, type,” “reno-cardio syndrome,” “children,” “acute kidney injury,” and “acute decompensated heart failure” from January 2000 to January 2021. A total of 14 pediatric studies were ultimately included and analyzed, comprising a combined population of 3608 children of which 32% had CRS. Of the 14 studies, 57% were based on type 1 CRS, 14% on types 2 and 3 CRS, and 7% were on types 4 and 5 CRS. The majority of included studies were prospective cohort, although a wide spectrum was observed in terms of patient age, comorbidities, etiologies, and treatment strategies. Commonly observed comorbidities in CRS type 1 were hematologic, oncologic, cardiology-related side effects, muscular dystrophy, and pneumonia/bronchiolitis. CRS, particularly type 1, is prevalent in children and has a significant risk of mortality. The current treatment regimen primarily involves diuretics, extracorporeal fluid removal, and treatment of underlying etiologies and comorbidities. |
format | Online Article Text |
id | pubmed-10158476 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-101584762023-05-05 Cardiorenal syndrome in the pediatric population: A systematic review Pradhan, Subal Kumar Adnani, Harsha Safadi, Rama Yerigeri, Keval Nayak, Snehamayee Raina, Rupesh Sinha, Rajiv Ann Pediatr Cardiol Review Article The concept of cardiorenal syndrome (CRS) is derived from the crosstalk between the heart and kidneys in pathological conditions. Despite the rising importance of CRS, there is a paucity of information on the understanding of its pathophysiology and management, increasing both morbidity and mortality for patients. This review summarizes the existing conceptual pathophysiology of different types of CRS and delves into the associated therapeutic modalities with a focus on pediatric cases. Prospective or retrospective observational studies, comparative studies, case reports, case–control, and cross-sectional studies that include pediatric patients with CRS were included in this review. Literature was searched using PubMed, EMBASE, and Google Scholar with keywords including “cardio-renal syndrome, type,” “reno-cardio syndrome,” “children,” “acute kidney injury,” and “acute decompensated heart failure” from January 2000 to January 2021. A total of 14 pediatric studies were ultimately included and analyzed, comprising a combined population of 3608 children of which 32% had CRS. Of the 14 studies, 57% were based on type 1 CRS, 14% on types 2 and 3 CRS, and 7% were on types 4 and 5 CRS. The majority of included studies were prospective cohort, although a wide spectrum was observed in terms of patient age, comorbidities, etiologies, and treatment strategies. Commonly observed comorbidities in CRS type 1 were hematologic, oncologic, cardiology-related side effects, muscular dystrophy, and pneumonia/bronchiolitis. CRS, particularly type 1, is prevalent in children and has a significant risk of mortality. The current treatment regimen primarily involves diuretics, extracorporeal fluid removal, and treatment of underlying etiologies and comorbidities. Wolters Kluwer - Medknow 2022 2023-03-01 /pmc/articles/PMC10158476/ /pubmed/37152514 http://dx.doi.org/10.4103/apc.apc_50_22 Text en Copyright: © 2023 Annals of Pediatric Cardiology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Review Article Pradhan, Subal Kumar Adnani, Harsha Safadi, Rama Yerigeri, Keval Nayak, Snehamayee Raina, Rupesh Sinha, Rajiv Cardiorenal syndrome in the pediatric population: A systematic review |
title | Cardiorenal syndrome in the pediatric population: A systematic review |
title_full | Cardiorenal syndrome in the pediatric population: A systematic review |
title_fullStr | Cardiorenal syndrome in the pediatric population: A systematic review |
title_full_unstemmed | Cardiorenal syndrome in the pediatric population: A systematic review |
title_short | Cardiorenal syndrome in the pediatric population: A systematic review |
title_sort | cardiorenal syndrome in the pediatric population: a systematic review |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10158476/ https://www.ncbi.nlm.nih.gov/pubmed/37152514 http://dx.doi.org/10.4103/apc.apc_50_22 |
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