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Cardiorenal syndrome in the pediatric population: A systematic review

The concept of cardiorenal syndrome (CRS) is derived from the crosstalk between the heart and kidneys in pathological conditions. Despite the rising importance of CRS, there is a paucity of information on the understanding of its pathophysiology and management, increasing both morbidity and mortalit...

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Autores principales: Pradhan, Subal Kumar, Adnani, Harsha, Safadi, Rama, Yerigeri, Keval, Nayak, Snehamayee, Raina, Rupesh, Sinha, Rajiv
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10158476/
https://www.ncbi.nlm.nih.gov/pubmed/37152514
http://dx.doi.org/10.4103/apc.apc_50_22
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author Pradhan, Subal Kumar
Adnani, Harsha
Safadi, Rama
Yerigeri, Keval
Nayak, Snehamayee
Raina, Rupesh
Sinha, Rajiv
author_facet Pradhan, Subal Kumar
Adnani, Harsha
Safadi, Rama
Yerigeri, Keval
Nayak, Snehamayee
Raina, Rupesh
Sinha, Rajiv
author_sort Pradhan, Subal Kumar
collection PubMed
description The concept of cardiorenal syndrome (CRS) is derived from the crosstalk between the heart and kidneys in pathological conditions. Despite the rising importance of CRS, there is a paucity of information on the understanding of its pathophysiology and management, increasing both morbidity and mortality for patients. This review summarizes the existing conceptual pathophysiology of different types of CRS and delves into the associated therapeutic modalities with a focus on pediatric cases. Prospective or retrospective observational studies, comparative studies, case reports, case–control, and cross-sectional studies that include pediatric patients with CRS were included in this review. Literature was searched using PubMed, EMBASE, and Google Scholar with keywords including “cardio-renal syndrome, type,” “reno-cardio syndrome,” “children,” “acute kidney injury,” and “acute decompensated heart failure” from January 2000 to January 2021. A total of 14 pediatric studies were ultimately included and analyzed, comprising a combined population of 3608 children of which 32% had CRS. Of the 14 studies, 57% were based on type 1 CRS, 14% on types 2 and 3 CRS, and 7% were on types 4 and 5 CRS. The majority of included studies were prospective cohort, although a wide spectrum was observed in terms of patient age, comorbidities, etiologies, and treatment strategies. Commonly observed comorbidities in CRS type 1 were hematologic, oncologic, cardiology-related side effects, muscular dystrophy, and pneumonia/bronchiolitis. CRS, particularly type 1, is prevalent in children and has a significant risk of mortality. The current treatment regimen primarily involves diuretics, extracorporeal fluid removal, and treatment of underlying etiologies and comorbidities.
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spelling pubmed-101584762023-05-05 Cardiorenal syndrome in the pediatric population: A systematic review Pradhan, Subal Kumar Adnani, Harsha Safadi, Rama Yerigeri, Keval Nayak, Snehamayee Raina, Rupesh Sinha, Rajiv Ann Pediatr Cardiol Review Article The concept of cardiorenal syndrome (CRS) is derived from the crosstalk between the heart and kidneys in pathological conditions. Despite the rising importance of CRS, there is a paucity of information on the understanding of its pathophysiology and management, increasing both morbidity and mortality for patients. This review summarizes the existing conceptual pathophysiology of different types of CRS and delves into the associated therapeutic modalities with a focus on pediatric cases. Prospective or retrospective observational studies, comparative studies, case reports, case–control, and cross-sectional studies that include pediatric patients with CRS were included in this review. Literature was searched using PubMed, EMBASE, and Google Scholar with keywords including “cardio-renal syndrome, type,” “reno-cardio syndrome,” “children,” “acute kidney injury,” and “acute decompensated heart failure” from January 2000 to January 2021. A total of 14 pediatric studies were ultimately included and analyzed, comprising a combined population of 3608 children of which 32% had CRS. Of the 14 studies, 57% were based on type 1 CRS, 14% on types 2 and 3 CRS, and 7% were on types 4 and 5 CRS. The majority of included studies were prospective cohort, although a wide spectrum was observed in terms of patient age, comorbidities, etiologies, and treatment strategies. Commonly observed comorbidities in CRS type 1 were hematologic, oncologic, cardiology-related side effects, muscular dystrophy, and pneumonia/bronchiolitis. CRS, particularly type 1, is prevalent in children and has a significant risk of mortality. The current treatment regimen primarily involves diuretics, extracorporeal fluid removal, and treatment of underlying etiologies and comorbidities. Wolters Kluwer - Medknow 2022 2023-03-01 /pmc/articles/PMC10158476/ /pubmed/37152514 http://dx.doi.org/10.4103/apc.apc_50_22 Text en Copyright: © 2023 Annals of Pediatric Cardiology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review Article
Pradhan, Subal Kumar
Adnani, Harsha
Safadi, Rama
Yerigeri, Keval
Nayak, Snehamayee
Raina, Rupesh
Sinha, Rajiv
Cardiorenal syndrome in the pediatric population: A systematic review
title Cardiorenal syndrome in the pediatric population: A systematic review
title_full Cardiorenal syndrome in the pediatric population: A systematic review
title_fullStr Cardiorenal syndrome in the pediatric population: A systematic review
title_full_unstemmed Cardiorenal syndrome in the pediatric population: A systematic review
title_short Cardiorenal syndrome in the pediatric population: A systematic review
title_sort cardiorenal syndrome in the pediatric population: a systematic review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10158476/
https://www.ncbi.nlm.nih.gov/pubmed/37152514
http://dx.doi.org/10.4103/apc.apc_50_22
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