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Rapid glycolytic activation accompanying innate immune responses: mechanisms and function
Innate immune responses to pathogens, mediated by activation of pattern recognition receptors and downstream signal transduction cascades, trigger rapid transcriptional and epigenetic changes to support increased expression of pro-inflammatory cytokines and other effector molecules. Innate immune ce...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10158531/ https://www.ncbi.nlm.nih.gov/pubmed/37153593 http://dx.doi.org/10.3389/fimmu.2023.1180488 |
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author | Namgaladze, Dmitry Brüne, Bernhard |
author_facet | Namgaladze, Dmitry Brüne, Bernhard |
author_sort | Namgaladze, Dmitry |
collection | PubMed |
description | Innate immune responses to pathogens, mediated by activation of pattern recognition receptors and downstream signal transduction cascades, trigger rapid transcriptional and epigenetic changes to support increased expression of pro-inflammatory cytokines and other effector molecules. Innate immune cells also rapidly rewire their metabolism. The most prominent metabolic alteration following innate immune activation is rapid up-regulation of glycolysis. In this mini-review, we summarize recent advances regarding the mechanisms of rapid glycolytic activation in innate immune cells, highlighting the relevant signaling components. We also discuss the impact of glycolytic activation on inflammatory responses, including the recently elucidated links of metabolism and epigenetics. Finally, we highlight unresolved mechanistic details of glycolytic activation and possible avenues of future research in this area. |
format | Online Article Text |
id | pubmed-10158531 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-101585312023-05-05 Rapid glycolytic activation accompanying innate immune responses: mechanisms and function Namgaladze, Dmitry Brüne, Bernhard Front Immunol Immunology Innate immune responses to pathogens, mediated by activation of pattern recognition receptors and downstream signal transduction cascades, trigger rapid transcriptional and epigenetic changes to support increased expression of pro-inflammatory cytokines and other effector molecules. Innate immune cells also rapidly rewire their metabolism. The most prominent metabolic alteration following innate immune activation is rapid up-regulation of glycolysis. In this mini-review, we summarize recent advances regarding the mechanisms of rapid glycolytic activation in innate immune cells, highlighting the relevant signaling components. We also discuss the impact of glycolytic activation on inflammatory responses, including the recently elucidated links of metabolism and epigenetics. Finally, we highlight unresolved mechanistic details of glycolytic activation and possible avenues of future research in this area. Frontiers Media S.A. 2023-04-20 /pmc/articles/PMC10158531/ /pubmed/37153593 http://dx.doi.org/10.3389/fimmu.2023.1180488 Text en Copyright © 2023 Namgaladze and Brüne https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Namgaladze, Dmitry Brüne, Bernhard Rapid glycolytic activation accompanying innate immune responses: mechanisms and function |
title | Rapid glycolytic activation accompanying innate immune responses: mechanisms and function |
title_full | Rapid glycolytic activation accompanying innate immune responses: mechanisms and function |
title_fullStr | Rapid glycolytic activation accompanying innate immune responses: mechanisms and function |
title_full_unstemmed | Rapid glycolytic activation accompanying innate immune responses: mechanisms and function |
title_short | Rapid glycolytic activation accompanying innate immune responses: mechanisms and function |
title_sort | rapid glycolytic activation accompanying innate immune responses: mechanisms and function |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10158531/ https://www.ncbi.nlm.nih.gov/pubmed/37153593 http://dx.doi.org/10.3389/fimmu.2023.1180488 |
work_keys_str_mv | AT namgaladzedmitry rapidglycolyticactivationaccompanyinginnateimmuneresponsesmechanismsandfunction AT brunebernhard rapidglycolyticactivationaccompanyinginnateimmuneresponsesmechanismsandfunction |