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Antiviral properties of trans-δ-viniferin derivatives against enveloped viruses

Over the last century, the number of epidemics caused by RNA viruses has increased and the current SARS-CoV-2 pandemic has taught us about the compelling need for ready-to-use broad-spectrum antivirals. In this scenario, natural products stand out as a major historical source of drugs. We analyzed t...

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Autores principales: Zwygart, Arnaud Charles-Antoine, Medaglia, Chiara, Huber, Robin, Poli, Romain, Marcourt, Laurence, Schnee, Sylvain, Michellod, Emilie, Mazel-Sanchez, Beryl, Constant, Samuel, Huang, Song, Bekliz, Meriem, Clément, Sophie, Gindro, Katia, Queiroz, Emerson Ferreira, Tapparel, Caroline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Masson SAS. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10158552/
https://www.ncbi.nlm.nih.gov/pubmed/37148860
http://dx.doi.org/10.1016/j.biopha.2023.114825
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author Zwygart, Arnaud Charles-Antoine
Medaglia, Chiara
Huber, Robin
Poli, Romain
Marcourt, Laurence
Schnee, Sylvain
Michellod, Emilie
Mazel-Sanchez, Beryl
Constant, Samuel
Huang, Song
Bekliz, Meriem
Clément, Sophie
Gindro, Katia
Queiroz, Emerson Ferreira
Tapparel, Caroline
author_facet Zwygart, Arnaud Charles-Antoine
Medaglia, Chiara
Huber, Robin
Poli, Romain
Marcourt, Laurence
Schnee, Sylvain
Michellod, Emilie
Mazel-Sanchez, Beryl
Constant, Samuel
Huang, Song
Bekliz, Meriem
Clément, Sophie
Gindro, Katia
Queiroz, Emerson Ferreira
Tapparel, Caroline
author_sort Zwygart, Arnaud Charles-Antoine
collection PubMed
description Over the last century, the number of epidemics caused by RNA viruses has increased and the current SARS-CoV-2 pandemic has taught us about the compelling need for ready-to-use broad-spectrum antivirals. In this scenario, natural products stand out as a major historical source of drugs. We analyzed the antiviral effect of 4 stilbene dimers [1 (trans-δ-viniferin); 2 (11’,13’-di-O-methyl-trans-δ-viniferin), 3 (11,13-di-O-methyl-trans-δ-viniferin); and 4 (11,13,11’,13’-tetra-O-methyl-trans-δ-viniferin)] obtained from plant substrates using chemoenzymatic synthesis against a panel of enveloped viruses. We report that compounds 2 and 3 display a broad-spectrum antiviral activity, being able to effectively inhibit several strains of Influenza Viruses (IV), SARS-CoV-2 Delta and, to some extent, Herpes Simplex Virus 2 (HSV-2). Interestingly, the mechanism of action differs for each virus. We observed both a direct virucidal and a cell-mediated effect against IV, with a high barrier to antiviral resistance; a restricted cell-mediated mechanism of action against SARS-CoV-2 Delta and a direct virustatic activity against HSV-2. Of note, while the effect was lost against IV in tissue culture models of human airway epithelia, the antiviral activity was confirmed in this relevant model for SARS-CoV-2 Delta. Our results suggest that stilbene dimer derivatives are good candidate models for the treatment of enveloped virus infections.
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spelling pubmed-101585522023-05-04 Antiviral properties of trans-δ-viniferin derivatives against enveloped viruses Zwygart, Arnaud Charles-Antoine Medaglia, Chiara Huber, Robin Poli, Romain Marcourt, Laurence Schnee, Sylvain Michellod, Emilie Mazel-Sanchez, Beryl Constant, Samuel Huang, Song Bekliz, Meriem Clément, Sophie Gindro, Katia Queiroz, Emerson Ferreira Tapparel, Caroline Biomed Pharmacother Article Over the last century, the number of epidemics caused by RNA viruses has increased and the current SARS-CoV-2 pandemic has taught us about the compelling need for ready-to-use broad-spectrum antivirals. In this scenario, natural products stand out as a major historical source of drugs. We analyzed the antiviral effect of 4 stilbene dimers [1 (trans-δ-viniferin); 2 (11’,13’-di-O-methyl-trans-δ-viniferin), 3 (11,13-di-O-methyl-trans-δ-viniferin); and 4 (11,13,11’,13’-tetra-O-methyl-trans-δ-viniferin)] obtained from plant substrates using chemoenzymatic synthesis against a panel of enveloped viruses. We report that compounds 2 and 3 display a broad-spectrum antiviral activity, being able to effectively inhibit several strains of Influenza Viruses (IV), SARS-CoV-2 Delta and, to some extent, Herpes Simplex Virus 2 (HSV-2). Interestingly, the mechanism of action differs for each virus. We observed both a direct virucidal and a cell-mediated effect against IV, with a high barrier to antiviral resistance; a restricted cell-mediated mechanism of action against SARS-CoV-2 Delta and a direct virustatic activity against HSV-2. Of note, while the effect was lost against IV in tissue culture models of human airway epithelia, the antiviral activity was confirmed in this relevant model for SARS-CoV-2 Delta. Our results suggest that stilbene dimer derivatives are good candidate models for the treatment of enveloped virus infections. Published by Elsevier Masson SAS. 2023-07 2023-05-04 /pmc/articles/PMC10158552/ /pubmed/37148860 http://dx.doi.org/10.1016/j.biopha.2023.114825 Text en © 2023 Published by Elsevier Masson SAS. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Zwygart, Arnaud Charles-Antoine
Medaglia, Chiara
Huber, Robin
Poli, Romain
Marcourt, Laurence
Schnee, Sylvain
Michellod, Emilie
Mazel-Sanchez, Beryl
Constant, Samuel
Huang, Song
Bekliz, Meriem
Clément, Sophie
Gindro, Katia
Queiroz, Emerson Ferreira
Tapparel, Caroline
Antiviral properties of trans-δ-viniferin derivatives against enveloped viruses
title Antiviral properties of trans-δ-viniferin derivatives against enveloped viruses
title_full Antiviral properties of trans-δ-viniferin derivatives against enveloped viruses
title_fullStr Antiviral properties of trans-δ-viniferin derivatives against enveloped viruses
title_full_unstemmed Antiviral properties of trans-δ-viniferin derivatives against enveloped viruses
title_short Antiviral properties of trans-δ-viniferin derivatives against enveloped viruses
title_sort antiviral properties of trans-δ-viniferin derivatives against enveloped viruses
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10158552/
https://www.ncbi.nlm.nih.gov/pubmed/37148860
http://dx.doi.org/10.1016/j.biopha.2023.114825
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