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Activation in Right Dorsolateral Prefrontal Cortex Underlies Stuttering Anticipation

People who stutter learn to anticipate many of their overt stuttering events. Despite the critical role of anticipation, particularly how responses to anticipation shape stuttering behaviors, the neural bases associated with anticipation are unknown. We used a novel approach to identify anticipated...

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Autores principales: Jackson, Eric S., Dravida, Swethasri, Zhang, Xian, Noah, J. Adam, Gracco, Vincent, Hirsch, Joy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MIT Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10158639/
https://www.ncbi.nlm.nih.gov/pubmed/37216062
http://dx.doi.org/10.1162/nol_a_00073
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author Jackson, Eric S.
Dravida, Swethasri
Zhang, Xian
Noah, J. Adam
Gracco, Vincent
Hirsch, Joy
author_facet Jackson, Eric S.
Dravida, Swethasri
Zhang, Xian
Noah, J. Adam
Gracco, Vincent
Hirsch, Joy
author_sort Jackson, Eric S.
collection PubMed
description People who stutter learn to anticipate many of their overt stuttering events. Despite the critical role of anticipation, particularly how responses to anticipation shape stuttering behaviors, the neural bases associated with anticipation are unknown. We used a novel approach to identify anticipated and unanticipated words, which were produced by 22 adult stutterers in a delayed-response task while hemodynamic activity was measured using functional near infrared spectroscopy (fNIRS). Twenty-two control participants were included such that each individualized set of anticipated and unanticipated words was produced by one stutterer and one control participant. We conducted an analysis on the right dorsolateral prefrontal cortex (R-DLPFC) based on converging lines of evidence from the stuttering and cognitive control literatures. We also assessed connectivity between the R-DLPFC and right supramarginal gyrus (R-SMG), two key nodes of the frontoparietal network (FPN), to assess the role of cognitive control, and particularly error-likelihood monitoring, in stuttering anticipation. All analyses focused on the five-second anticipation phase preceding the go signal to produce speech. The results indicate that anticipated words are associated with elevated activation in the R-DLPFC, and that compared to non-stutterers, stutterers exhibit greater activity in the R-DLPFC, irrespective of anticipation. Further, anticipated words are associated with reduced connectivity between the R-DLPFC and R-SMG. These findings highlight the potential roles of the R-DLPFC and the greater FPN as a neural substrate of stuttering anticipation. The results also support previous accounts of error-likelihood monitoring and action-stopping in stuttering anticipation. Overall, this work offers numerous directions for future research with clinical implications for targeted neuromodulation.
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spelling pubmed-101586392023-05-19 Activation in Right Dorsolateral Prefrontal Cortex Underlies Stuttering Anticipation Jackson, Eric S. Dravida, Swethasri Zhang, Xian Noah, J. Adam Gracco, Vincent Hirsch, Joy Neurobiol Lang (Camb) Research Article People who stutter learn to anticipate many of their overt stuttering events. Despite the critical role of anticipation, particularly how responses to anticipation shape stuttering behaviors, the neural bases associated with anticipation are unknown. We used a novel approach to identify anticipated and unanticipated words, which were produced by 22 adult stutterers in a delayed-response task while hemodynamic activity was measured using functional near infrared spectroscopy (fNIRS). Twenty-two control participants were included such that each individualized set of anticipated and unanticipated words was produced by one stutterer and one control participant. We conducted an analysis on the right dorsolateral prefrontal cortex (R-DLPFC) based on converging lines of evidence from the stuttering and cognitive control literatures. We also assessed connectivity between the R-DLPFC and right supramarginal gyrus (R-SMG), two key nodes of the frontoparietal network (FPN), to assess the role of cognitive control, and particularly error-likelihood monitoring, in stuttering anticipation. All analyses focused on the five-second anticipation phase preceding the go signal to produce speech. The results indicate that anticipated words are associated with elevated activation in the R-DLPFC, and that compared to non-stutterers, stutterers exhibit greater activity in the R-DLPFC, irrespective of anticipation. Further, anticipated words are associated with reduced connectivity between the R-DLPFC and R-SMG. These findings highlight the potential roles of the R-DLPFC and the greater FPN as a neural substrate of stuttering anticipation. The results also support previous accounts of error-likelihood monitoring and action-stopping in stuttering anticipation. Overall, this work offers numerous directions for future research with clinical implications for targeted neuromodulation. MIT Press 2022-08-17 /pmc/articles/PMC10158639/ /pubmed/37216062 http://dx.doi.org/10.1162/nol_a_00073 Text en © 2022 Massachusetts Institute of Technology https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. For a full description of the license, please visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Jackson, Eric S.
Dravida, Swethasri
Zhang, Xian
Noah, J. Adam
Gracco, Vincent
Hirsch, Joy
Activation in Right Dorsolateral Prefrontal Cortex Underlies Stuttering Anticipation
title Activation in Right Dorsolateral Prefrontal Cortex Underlies Stuttering Anticipation
title_full Activation in Right Dorsolateral Prefrontal Cortex Underlies Stuttering Anticipation
title_fullStr Activation in Right Dorsolateral Prefrontal Cortex Underlies Stuttering Anticipation
title_full_unstemmed Activation in Right Dorsolateral Prefrontal Cortex Underlies Stuttering Anticipation
title_short Activation in Right Dorsolateral Prefrontal Cortex Underlies Stuttering Anticipation
title_sort activation in right dorsolateral prefrontal cortex underlies stuttering anticipation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10158639/
https://www.ncbi.nlm.nih.gov/pubmed/37216062
http://dx.doi.org/10.1162/nol_a_00073
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