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Evaluation of Punarnavadi Mandura for haematinic activity against mercuric chloride-induced anemia in albino rats

BACKGROUND: Punarnavadi Mandura, a compound Ayurvedic formulation, is one of the most commonly used medicine in the treatment of anemia (Pandu) in Ayurveda. The safety profile of this formulation is well established; however, no pharmacological study has been reported to provide the scientific basis...

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Autores principales: Kori, V. K., Ravishankar, B., Patel, K. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10158649/
https://www.ncbi.nlm.nih.gov/pubmed/37153070
http://dx.doi.org/10.4103/ayu.AYU_294_20
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author Kori, V. K.
Ravishankar, B.
Patel, K. S.
author_facet Kori, V. K.
Ravishankar, B.
Patel, K. S.
author_sort Kori, V. K.
collection PubMed
description BACKGROUND: Punarnavadi Mandura, a compound Ayurvedic formulation, is one of the most commonly used medicine in the treatment of anemia (Pandu) in Ayurveda. The safety profile of this formulation is well established; however, no pharmacological study has been reported to provide the scientific basis for its use in the treatment of anemia. AIM: To evaluate the hematinic effect of Punarnavadi Mandura against mercuric chloride-induced anemia in albino rats. MATERIALS AND METHODS: The test drug (Punarnavadi Mandura) was suspended in distilled water and administered orally in a dose of 450 mg/kg for 30 days in rats. Anemia was induced by simultaneous administration of mercuric chloride (9 mg/kg) for 30 consecutive days. Body weight was noted for each animals. At the end, haematological parameters, anaemia markers like serum iron, ferritin, and total iron binding capacity (TIBC), as well as relative weight of organs and histopathology investigation, were examined. RESULTS: Exposure of mercuric chloride to rats for 30 days resulted in a significant decrease of body weight, an increase in the weight of the liver and kidney and a decrease in hemoglobin content. It also decreased serum ferritin to a significant extent and increased serum TIBC. Histopathology of the liver shows macro fatty changes, vacuolization, marked necrosis, and severe degenerative changes, while the kidney shows cell infiltration. All these changes were significantly attenuated by the administration of Punarnavadi Mandura. CONCLUSION: The present data indicate that Punarnavadi Mandura has possessing marked cytoprotective activity, significantly attenuated the HgCl(2)-induced adverse changes on red blood cell related parameters, and showing hematinic activity in albino rats.
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spelling pubmed-101586492023-05-05 Evaluation of Punarnavadi Mandura for haematinic activity against mercuric chloride-induced anemia in albino rats Kori, V. K. Ravishankar, B. Patel, K. S. Ayu Original Article BACKGROUND: Punarnavadi Mandura, a compound Ayurvedic formulation, is one of the most commonly used medicine in the treatment of anemia (Pandu) in Ayurveda. The safety profile of this formulation is well established; however, no pharmacological study has been reported to provide the scientific basis for its use in the treatment of anemia. AIM: To evaluate the hematinic effect of Punarnavadi Mandura against mercuric chloride-induced anemia in albino rats. MATERIALS AND METHODS: The test drug (Punarnavadi Mandura) was suspended in distilled water and administered orally in a dose of 450 mg/kg for 30 days in rats. Anemia was induced by simultaneous administration of mercuric chloride (9 mg/kg) for 30 consecutive days. Body weight was noted for each animals. At the end, haematological parameters, anaemia markers like serum iron, ferritin, and total iron binding capacity (TIBC), as well as relative weight of organs and histopathology investigation, were examined. RESULTS: Exposure of mercuric chloride to rats for 30 days resulted in a significant decrease of body weight, an increase in the weight of the liver and kidney and a decrease in hemoglobin content. It also decreased serum ferritin to a significant extent and increased serum TIBC. Histopathology of the liver shows macro fatty changes, vacuolization, marked necrosis, and severe degenerative changes, while the kidney shows cell infiltration. All these changes were significantly attenuated by the administration of Punarnavadi Mandura. CONCLUSION: The present data indicate that Punarnavadi Mandura has possessing marked cytoprotective activity, significantly attenuated the HgCl(2)-induced adverse changes on red blood cell related parameters, and showing hematinic activity in albino rats. Wolters Kluwer - Medknow 2021 2023-03-16 /pmc/articles/PMC10158649/ /pubmed/37153070 http://dx.doi.org/10.4103/ayu.AYU_294_20 Text en Copyright: © 2023 AYU (An International Quarterly Journal of Research in Ayurveda) https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Kori, V. K.
Ravishankar, B.
Patel, K. S.
Evaluation of Punarnavadi Mandura for haematinic activity against mercuric chloride-induced anemia in albino rats
title Evaluation of Punarnavadi Mandura for haematinic activity against mercuric chloride-induced anemia in albino rats
title_full Evaluation of Punarnavadi Mandura for haematinic activity against mercuric chloride-induced anemia in albino rats
title_fullStr Evaluation of Punarnavadi Mandura for haematinic activity against mercuric chloride-induced anemia in albino rats
title_full_unstemmed Evaluation of Punarnavadi Mandura for haematinic activity against mercuric chloride-induced anemia in albino rats
title_short Evaluation of Punarnavadi Mandura for haematinic activity against mercuric chloride-induced anemia in albino rats
title_sort evaluation of punarnavadi mandura for haematinic activity against mercuric chloride-induced anemia in albino rats
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10158649/
https://www.ncbi.nlm.nih.gov/pubmed/37153070
http://dx.doi.org/10.4103/ayu.AYU_294_20
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