Genome-wide CRISPR Screen Reveals RAB10 as a Synthetic Lethal Gene in Colorectal and Pancreatic Cancers Carrying SMAD4 Loss

The TGFβ signaling mediator SMAD4 is frequently mutated or deleted in colorectal and pancreatic cancers. SMAD4 acts as a tumor suppressor and its loss is associated with poorer patient outcomes. The purpose of this study was to find synthetic lethal interactions with SMAD4 deficiency to find novel t...

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Detalles Bibliográficos
Autores principales: Erasimus, Hélène, Kolnik, Vanessa, Lacroix, Frédéric, Sidhu, Sukhvinder, D'Agostino, Stéphane, Lemaitre, Olivier, Rohaut, Alexandre, Sanchez, Isabelle, Thill, Gilbert, Didier, Michel, Debussche, Laurent, Marcireau, Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10158796/
https://www.ncbi.nlm.nih.gov/pubmed/37377893
http://dx.doi.org/10.1158/2767-9764.CRC-22-0301

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