Secukinumab for the treatment of generalized pustular psoriasis: A case report

Generalized pustular psoriasis (GPP) is a rare subtype of psoriasis that manifests as a generalized pustular eruption. PATIENT CONCERNS: A 31-year-old female was admitted to the hospital in June 2021 with a widespread erythematous, itchy, and scaly rash for a week. The patient has a 10-year history of psoriasis vulgaris. DIAGNOSIS: GPP complicated by a late-stage viral infection and early-stage renal damage. INTERVENTIONS: Weekly subcutaneous injections of 300 mg of secukinumab for a month, followed by monthly (every 4 weeks) injections of 300 mg of secukinumab for 20 weeks. OUTCOMES: The symptoms of pustules and erythema were reduced, and the patient reported pain relief soon after the first injection. The patient had no serious adverse reactions during treatment and follow-up. CONCLUSIONS: Secukinumab might be an optional treatment strategy for GPP.