The role of prolactin/vasoinhibins in cardiovascular diseases

Prolactin (PRL) is a polypeptide hormone that is mainly synthesized and secreted by the lactotroph cells of the pituitary. There are two main isoforms of PRL: 23‐kDa PRL (named full‐length PRL) and vasoinhibins (including 5.6–18 kDa fragments). Both act as circulating hormones and cytokines to stimu...

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Autores principales: Zhao, Hui, Gong, Sugang, Shi, Yongcong, Luo, Cijun, Qiu, Hongling, He, Jing, Sun, Yuanyuan, Huang, Yuxia, Wang, Shang, Miao, Yuqing, Wu, Wenhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Themed Section: Study on Cardiovascular and Cerebrovascular Diseases
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10158951/
https://www.ncbi.nlm.nih.gov/pubmed/35923071
http://dx.doi.org/10.1002/ame2.12264
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author Zhao, Hui
Gong, Sugang
Shi, Yongcong
Luo, Cijun
Qiu, Hongling
He, Jing
Sun, Yuanyuan
Huang, Yuxia
Wang, Shang
Miao, Yuqing
Wu, Wenhui
author_facet Zhao, Hui
Gong, Sugang
Shi, Yongcong
Luo, Cijun
Qiu, Hongling
He, Jing
Sun, Yuanyuan
Huang, Yuxia
Wang, Shang
Miao, Yuqing
Wu, Wenhui
author_sort Zhao, Hui
collection PubMed
description Prolactin (PRL) is a polypeptide hormone that is mainly synthesized and secreted by the lactotroph cells of the pituitary. There are two main isoforms of PRL: 23‐kDa PRL (named full‐length PRL) and vasoinhibins (including 5.6–18 kDa fragments). Both act as circulating hormones and cytokines to stimulate or inhibit vascular formation at different stages and neovascularization, including endothelial cell proliferation and migration, protease production, and apoptosis. However, their effects on vascular function and cardiovascular diseases are different or even contrary. In addition to the structure, secretion regulation, and signal transduction of PRL/vasoinhibins, this review focuses on the pathological mechanism and clinical significance of PRL/vasoinhibins in cardiovascular diseases.
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spelling pubmed-101589512023-05-05 The role of prolactin/vasoinhibins in cardiovascular diseases Zhao, Hui Gong, Sugang Shi, Yongcong Luo, Cijun Qiu, Hongling He, Jing Sun, Yuanyuan Huang, Yuxia Wang, Shang Miao, Yuqing Wu, Wenhui Animal Model Exp Med Themed Section: Study on Cardiovascular and Cerebrovascular Diseases Prolactin (PRL) is a polypeptide hormone that is mainly synthesized and secreted by the lactotroph cells of the pituitary. There are two main isoforms of PRL: 23‐kDa PRL (named full‐length PRL) and vasoinhibins (including 5.6–18 kDa fragments). Both act as circulating hormones and cytokines to stimulate or inhibit vascular formation at different stages and neovascularization, including endothelial cell proliferation and migration, protease production, and apoptosis. However, their effects on vascular function and cardiovascular diseases are different or even contrary. In addition to the structure, secretion regulation, and signal transduction of PRL/vasoinhibins, this review focuses on the pathological mechanism and clinical significance of PRL/vasoinhibins in cardiovascular diseases. John Wiley and Sons Inc. 2022-08-03 /pmc/articles/PMC10158951/ /pubmed/35923071 http://dx.doi.org/10.1002/ame2.12264 Text en © 2022 The Authors. Animal Models and Experimental Medicine published by John Wiley & Sons Australia, Ltd on behalf of The Chinese Association for Laboratory Animal Sciences. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Themed Section: Study on Cardiovascular and Cerebrovascular Diseases
Zhao, Hui
Gong, Sugang
Shi, Yongcong
Luo, Cijun
Qiu, Hongling
He, Jing
Sun, Yuanyuan
Huang, Yuxia
Wang, Shang
Miao, Yuqing
Wu, Wenhui
The role of prolactin/vasoinhibins in cardiovascular diseases
title The role of prolactin/vasoinhibins in cardiovascular diseases
title_full The role of prolactin/vasoinhibins in cardiovascular diseases
title_fullStr The role of prolactin/vasoinhibins in cardiovascular diseases
title_full_unstemmed The role of prolactin/vasoinhibins in cardiovascular diseases
title_short The role of prolactin/vasoinhibins in cardiovascular diseases
title_sort role of prolactin/vasoinhibins in cardiovascular diseases
topic Themed Section: Study on Cardiovascular and Cerebrovascular Diseases
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10158951/
https://www.ncbi.nlm.nih.gov/pubmed/35923071
http://dx.doi.org/10.1002/ame2.12264
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