Design and off-target prediction for antisense oligomers targeting bacterial mRNAs with the MASON web server

Antisense oligomers (ASOs), such as peptide nucleic acids (PNAs), designed to inhibit the translation of essential bacterial genes, have emerged as attractive sequence- and species-specific programmable RNA antibiotics. Yet, potential drawbacks include unwanted side effects caused by their binding t...

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Detalles Bibliográficos
Autores principales: Jung, Jakob, Popella, Linda, Do, Phuong Thao, Pfau, Patrick, Vogel, Jörg, Barquist, Lars
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2023
Materias:
Bioinformatics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10158992/
https://www.ncbi.nlm.nih.gov/pubmed/36750372
http://dx.doi.org/10.1261/rna.079263.122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10158992/
https://www.ncbi.nlm.nih.gov/pubmed/36750372
http://dx.doi.org/10.1261/rna.079263.122

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