RyR2 regulates store-operated Ca(2+) entry, phospholipase C activity, and electrical excitability in the insulinoma cell line INS-1

The ER Ca(2+) channel ryanodine receptor 2 (RyR2) is required for maintenance of insulin content and glucose-stimulated insulin secretion, in part, via regulation of the protein IRBIT in the insulinoma cell line INS-1. Here, we examined store-operated and depolarization-dependent Ca(2+)entry using I...

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Detalles Bibliográficos
Autores principales: Harvey, Kyle E., Tang, Shiqi, LaVigne, Emily K., Pratt, Evan P. S., Hockerman, Gregory H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10159205/
https://www.ncbi.nlm.nih.gov/pubmed/37141277
http://dx.doi.org/10.1371/journal.pone.0285316

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10159205/
https://www.ncbi.nlm.nih.gov/pubmed/37141277
http://dx.doi.org/10.1371/journal.pone.0285316

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