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A Rare Case of Metastasis of Gastric Adenocarcinoma to the Leptomeninges
Leptomeningeal carcinomatosis (LMC) is defined as the diffuse infiltration of malignant cells throughout the pia and arachnoid membrane. LMC is commonly observed in patients with leukemia, lymphoma, and breast and lung cancer. The prevalence of LMC spread in patients with primary gastric malignancy...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10159219/ https://www.ncbi.nlm.nih.gov/pubmed/37153327 http://dx.doi.org/10.7759/cureus.37120 |
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author | Doshi, Krishna James, Edward |
author_facet | Doshi, Krishna James, Edward |
author_sort | Doshi, Krishna |
collection | PubMed |
description | Leptomeningeal carcinomatosis (LMC) is defined as the diffuse infiltration of malignant cells throughout the pia and arachnoid membrane. LMC is commonly observed in patients with leukemia, lymphoma, and breast and lung cancer. The prevalence of LMC spread in patients with primary gastric malignancy is very rare. Due to its devastating neurological complications and high mortality, it is difficult to assess the associated clinical features, treatment outcomes, and prognostic factors. Current treatment options include intra-thecal chemotherapy, radiotherapy, and supportive care with a median survival of three to four months. LMC is a rare manifestation of gastric cancer and is an extremely fatal disease. Therefore, it is difficult to distinguish LMC from other neurological etiologies. We present a unique case of an individual who presented with headaches and was found to have LMC. |
format | Online Article Text |
id | pubmed-10159219 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-101592192023-05-05 A Rare Case of Metastasis of Gastric Adenocarcinoma to the Leptomeninges Doshi, Krishna James, Edward Cureus Internal Medicine Leptomeningeal carcinomatosis (LMC) is defined as the diffuse infiltration of malignant cells throughout the pia and arachnoid membrane. LMC is commonly observed in patients with leukemia, lymphoma, and breast and lung cancer. The prevalence of LMC spread in patients with primary gastric malignancy is very rare. Due to its devastating neurological complications and high mortality, it is difficult to assess the associated clinical features, treatment outcomes, and prognostic factors. Current treatment options include intra-thecal chemotherapy, radiotherapy, and supportive care with a median survival of three to four months. LMC is a rare manifestation of gastric cancer and is an extremely fatal disease. Therefore, it is difficult to distinguish LMC from other neurological etiologies. We present a unique case of an individual who presented with headaches and was found to have LMC. Cureus 2023-04-04 /pmc/articles/PMC10159219/ /pubmed/37153327 http://dx.doi.org/10.7759/cureus.37120 Text en Copyright © 2023, Doshi et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Internal Medicine Doshi, Krishna James, Edward A Rare Case of Metastasis of Gastric Adenocarcinoma to the Leptomeninges |
title | A Rare Case of Metastasis of Gastric Adenocarcinoma to the Leptomeninges |
title_full | A Rare Case of Metastasis of Gastric Adenocarcinoma to the Leptomeninges |
title_fullStr | A Rare Case of Metastasis of Gastric Adenocarcinoma to the Leptomeninges |
title_full_unstemmed | A Rare Case of Metastasis of Gastric Adenocarcinoma to the Leptomeninges |
title_short | A Rare Case of Metastasis of Gastric Adenocarcinoma to the Leptomeninges |
title_sort | rare case of metastasis of gastric adenocarcinoma to the leptomeninges |
topic | Internal Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10159219/ https://www.ncbi.nlm.nih.gov/pubmed/37153327 http://dx.doi.org/10.7759/cureus.37120 |
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