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A Rare Case of Metastasis of Gastric Adenocarcinoma to the Leptomeninges

Leptomeningeal carcinomatosis (LMC) is defined as the diffuse infiltration of malignant cells throughout the pia and arachnoid membrane. LMC is commonly observed in patients with leukemia, lymphoma, and breast and lung cancer. The prevalence of LMC spread in patients with primary gastric malignancy...

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Detalles Bibliográficos
Autores principales: Doshi, Krishna, James, Edward
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10159219/
https://www.ncbi.nlm.nih.gov/pubmed/37153327
http://dx.doi.org/10.7759/cureus.37120
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author Doshi, Krishna
James, Edward
author_facet Doshi, Krishna
James, Edward
author_sort Doshi, Krishna
collection PubMed
description Leptomeningeal carcinomatosis (LMC) is defined as the diffuse infiltration of malignant cells throughout the pia and arachnoid membrane. LMC is commonly observed in patients with leukemia, lymphoma, and breast and lung cancer. The prevalence of LMC spread in patients with primary gastric malignancy is very rare. Due to its devastating neurological complications and high mortality, it is difficult to assess the associated clinical features, treatment outcomes, and prognostic factors. Current treatment options include intra-thecal chemotherapy, radiotherapy, and supportive care with a median survival of three to four months. LMC is a rare manifestation of gastric cancer and is an extremely fatal disease. Therefore, it is difficult to distinguish LMC from other neurological etiologies. We present a unique case of an individual who presented with headaches and was found to have LMC.
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spelling pubmed-101592192023-05-05 A Rare Case of Metastasis of Gastric Adenocarcinoma to the Leptomeninges Doshi, Krishna James, Edward Cureus Internal Medicine Leptomeningeal carcinomatosis (LMC) is defined as the diffuse infiltration of malignant cells throughout the pia and arachnoid membrane. LMC is commonly observed in patients with leukemia, lymphoma, and breast and lung cancer. The prevalence of LMC spread in patients with primary gastric malignancy is very rare. Due to its devastating neurological complications and high mortality, it is difficult to assess the associated clinical features, treatment outcomes, and prognostic factors. Current treatment options include intra-thecal chemotherapy, radiotherapy, and supportive care with a median survival of three to four months. LMC is a rare manifestation of gastric cancer and is an extremely fatal disease. Therefore, it is difficult to distinguish LMC from other neurological etiologies. We present a unique case of an individual who presented with headaches and was found to have LMC. Cureus 2023-04-04 /pmc/articles/PMC10159219/ /pubmed/37153327 http://dx.doi.org/10.7759/cureus.37120 Text en Copyright © 2023, Doshi et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Doshi, Krishna
James, Edward
A Rare Case of Metastasis of Gastric Adenocarcinoma to the Leptomeninges
title A Rare Case of Metastasis of Gastric Adenocarcinoma to the Leptomeninges
title_full A Rare Case of Metastasis of Gastric Adenocarcinoma to the Leptomeninges
title_fullStr A Rare Case of Metastasis of Gastric Adenocarcinoma to the Leptomeninges
title_full_unstemmed A Rare Case of Metastasis of Gastric Adenocarcinoma to the Leptomeninges
title_short A Rare Case of Metastasis of Gastric Adenocarcinoma to the Leptomeninges
title_sort rare case of metastasis of gastric adenocarcinoma to the leptomeninges
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10159219/
https://www.ncbi.nlm.nih.gov/pubmed/37153327
http://dx.doi.org/10.7759/cureus.37120
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