A 13-year patient journey of infant giant clival chordoma: case report and literature review

Chordomas are rare malignant bone tumours that develop from the ectopic remnants of the embryonic notochord. In contrast to adults, the majority in children under 16 present intra-cranially (63%). In 2006, we reported the youngest case of a large clival chordoma, a 15-week old baby, the second case...

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Autores principales: Apps, J., Gagen, R., Neumann, E., Solanki, G., English, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10159969/
https://www.ncbi.nlm.nih.gov/pubmed/36414866
http://dx.doi.org/10.1007/s00381-022-05749-4
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author Apps, J.
Gagen, R.
Neumann, E.
Solanki, G.
English, M.
author_facet Apps, J.
Gagen, R.
Neumann, E.
Solanki, G.
English, M.
author_sort Apps, J.
collection PubMed
description Chordomas are rare malignant bone tumours that develop from the ectopic remnants of the embryonic notochord. In contrast to adults, the majority in children under 16 present intra-cranially (63%). In 2006, we reported the youngest case of a large clival chordoma, a 15-week old baby, the second case to present without skull base involvement and the fourth case of chordoma in a patient with tuberous sclerosis (TS) Kombogiorgas (Childs Nerv Syst 22(10):1369–1374, 2006). In this report, we provide an update on this patient’s journey through a range of therapeutic options and summarize an update of the literature, since 2006, for this patient group. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00381-022-05749-4.
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spelling pubmed-101599692023-05-06 A 13-year patient journey of infant giant clival chordoma: case report and literature review Apps, J. Gagen, R. Neumann, E. Solanki, G. English, M. Childs Nerv Syst Case Report Chordomas are rare malignant bone tumours that develop from the ectopic remnants of the embryonic notochord. In contrast to adults, the majority in children under 16 present intra-cranially (63%). In 2006, we reported the youngest case of a large clival chordoma, a 15-week old baby, the second case to present without skull base involvement and the fourth case of chordoma in a patient with tuberous sclerosis (TS) Kombogiorgas (Childs Nerv Syst 22(10):1369–1374, 2006). In this report, we provide an update on this patient’s journey through a range of therapeutic options and summarize an update of the literature, since 2006, for this patient group. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00381-022-05749-4. Springer Berlin Heidelberg 2022-11-22 2023 /pmc/articles/PMC10159969/ /pubmed/36414866 http://dx.doi.org/10.1007/s00381-022-05749-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Case Report
Apps, J.
Gagen, R.
Neumann, E.
Solanki, G.
English, M.
A 13-year patient journey of infant giant clival chordoma: case report and literature review
title A 13-year patient journey of infant giant clival chordoma: case report and literature review
title_full A 13-year patient journey of infant giant clival chordoma: case report and literature review
title_fullStr A 13-year patient journey of infant giant clival chordoma: case report and literature review
title_full_unstemmed A 13-year patient journey of infant giant clival chordoma: case report and literature review
title_short A 13-year patient journey of infant giant clival chordoma: case report and literature review
title_sort 13-year patient journey of infant giant clival chordoma: case report and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10159969/
https://www.ncbi.nlm.nih.gov/pubmed/36414866
http://dx.doi.org/10.1007/s00381-022-05749-4
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