Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease

Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in the world. High levels of free fatty acids in the liver impair hepatic lysosomal acidification and reduce autophagic flux. We investigate whether restoration of lysosomal function in NAFLD recovers autophagic flux, mitocho...

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Detalles Bibliográficos
Autores principales: Zeng, Jialiu, Acin-Perez, Rebeca, Assali, Essam A., Martin, Andrew, Brownstein, Alexandra J., Petcherski, Anton, Fernández-del-Rio, Lucía, Xiao, Ruiqing, Lo, Chih Hung, Shum, Michaël, Liesa, Marc, Han, Xue, Shirihai, Orian S., Grinstaff, Mark W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10160018/
https://www.ncbi.nlm.nih.gov/pubmed/37142604
http://dx.doi.org/10.1038/s41467-023-38165-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10160018/
https://www.ncbi.nlm.nih.gov/pubmed/37142604
http://dx.doi.org/10.1038/s41467-023-38165-6

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