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A clinical study of the correlation between metabolic-associated fatty liver disease and coronary plaque pattern

Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome (MetS) and has been correlated with coronary atherosclerosis (CAS). Since NAFLD was renamed metabolic-associated fatty liver disease(MAFLD) in 2020, no studies have evaluated the correlation between MAFLD and...

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Autores principales: Zhang, Zhijiao, Zheng, Mengyao, Lei, Hongtao, Jiang, Zimeng, Chen, Yuhang, He, Haiyu, Zhao, Gongfang, Huang, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10160090/
https://www.ncbi.nlm.nih.gov/pubmed/37142746
http://dx.doi.org/10.1038/s41598-023-34462-8
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author Zhang, Zhijiao
Zheng, Mengyao
Lei, Hongtao
Jiang, Zimeng
Chen, Yuhang
He, Haiyu
Zhao, Gongfang
Huang, Hua
author_facet Zhang, Zhijiao
Zheng, Mengyao
Lei, Hongtao
Jiang, Zimeng
Chen, Yuhang
He, Haiyu
Zhao, Gongfang
Huang, Hua
author_sort Zhang, Zhijiao
collection PubMed
description Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome (MetS) and has been correlated with coronary atherosclerosis (CAS). Since NAFLD was renamed metabolic-associated fatty liver disease(MAFLD) in 2020, no studies have evaluated the correlation between MAFLD and CAS. The aim of this study was to evaluate the relationship between MAFLD and CAS. A total of 1330 patients underwent continuous coronary computed tomography angiography (CCTA) and abdominal ultrasound as part of a routine physical examination. Ultrasonography was used to assess fatty liver, and CCTA was used to assess coronary artery plaques, degree of stenosis, and diseased blood vessels. Univariate and multivariate logistic regression analyses were performed with plaque type and degree of stenosis as dependent variables and MAFLD and traditional cardiovascular risk factors as independent variables to analyze the correlation between MAFLD and CAS. Among the 1164 patients, 680 (58.4%) were diagnosed with MAFLD through a combination of ultrasound and auxiliary examinations. Compared with the non-MAFLD group, the MAFLD group had more cardiovascular risk factors,and the MAFLD group had more likely to have coronary atherosclerosis, coronary stenosis and multiple coronary artery stenosis.In the univariate logistic regression, MAFLD was significantly correlated with overall plaque, calcified plaques, noncalcified plaques, mixed plaques,and significant stenosis in the coronary arteries.(p < 0.05). After adjusting for cardiovascular risk factors , MAFLD was correlated with noncalcified plaques (1.67; 95% confidence interval (CI) 1.15–2.43; p = 0.007) and mixed plaques (1.54; 95% CI 1.10–2.16; p = 0.011). In this study, MAFLD group had more cardiovascular risk factors, MAFLD was correlated with coronary atherosclerosis,and significant stenosis.Further study found independent associations between MAFLD and noncalcified plaques and mixed plaques, which suggest a clinically relevant link between MAFLD and coronary atherosclerosis.
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spelling pubmed-101600902023-05-06 A clinical study of the correlation between metabolic-associated fatty liver disease and coronary plaque pattern Zhang, Zhijiao Zheng, Mengyao Lei, Hongtao Jiang, Zimeng Chen, Yuhang He, Haiyu Zhao, Gongfang Huang, Hua Sci Rep Article Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome (MetS) and has been correlated with coronary atherosclerosis (CAS). Since NAFLD was renamed metabolic-associated fatty liver disease(MAFLD) in 2020, no studies have evaluated the correlation between MAFLD and CAS. The aim of this study was to evaluate the relationship between MAFLD and CAS. A total of 1330 patients underwent continuous coronary computed tomography angiography (CCTA) and abdominal ultrasound as part of a routine physical examination. Ultrasonography was used to assess fatty liver, and CCTA was used to assess coronary artery plaques, degree of stenosis, and diseased blood vessels. Univariate and multivariate logistic regression analyses were performed with plaque type and degree of stenosis as dependent variables and MAFLD and traditional cardiovascular risk factors as independent variables to analyze the correlation between MAFLD and CAS. Among the 1164 patients, 680 (58.4%) were diagnosed with MAFLD through a combination of ultrasound and auxiliary examinations. Compared with the non-MAFLD group, the MAFLD group had more cardiovascular risk factors,and the MAFLD group had more likely to have coronary atherosclerosis, coronary stenosis and multiple coronary artery stenosis.In the univariate logistic regression, MAFLD was significantly correlated with overall plaque, calcified plaques, noncalcified plaques, mixed plaques,and significant stenosis in the coronary arteries.(p < 0.05). After adjusting for cardiovascular risk factors , MAFLD was correlated with noncalcified plaques (1.67; 95% confidence interval (CI) 1.15–2.43; p = 0.007) and mixed plaques (1.54; 95% CI 1.10–2.16; p = 0.011). In this study, MAFLD group had more cardiovascular risk factors, MAFLD was correlated with coronary atherosclerosis,and significant stenosis.Further study found independent associations between MAFLD and noncalcified plaques and mixed plaques, which suggest a clinically relevant link between MAFLD and coronary atherosclerosis. Nature Publishing Group UK 2023-05-04 /pmc/articles/PMC10160090/ /pubmed/37142746 http://dx.doi.org/10.1038/s41598-023-34462-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Zhang, Zhijiao
Zheng, Mengyao
Lei, Hongtao
Jiang, Zimeng
Chen, Yuhang
He, Haiyu
Zhao, Gongfang
Huang, Hua
A clinical study of the correlation between metabolic-associated fatty liver disease and coronary plaque pattern
title A clinical study of the correlation between metabolic-associated fatty liver disease and coronary plaque pattern
title_full A clinical study of the correlation between metabolic-associated fatty liver disease and coronary plaque pattern
title_fullStr A clinical study of the correlation between metabolic-associated fatty liver disease and coronary plaque pattern
title_full_unstemmed A clinical study of the correlation between metabolic-associated fatty liver disease and coronary plaque pattern
title_short A clinical study of the correlation between metabolic-associated fatty liver disease and coronary plaque pattern
title_sort clinical study of the correlation between metabolic-associated fatty liver disease and coronary plaque pattern
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10160090/
https://www.ncbi.nlm.nih.gov/pubmed/37142746
http://dx.doi.org/10.1038/s41598-023-34462-8
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