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Thrombotisch-thrombozytopenische Purpura – eine differenzialdiagnostische Herausforderung im Notfall

Thrombotic thrombocytopenic purpura (TTP), which comprises thrombocytopenia, elevated lactate dehydrogenase levels, and anemia in the combination of organ involvement, is a rare but life-threatening condition associated with an extremely high lethality in the acute phase if left untreated. Using the...

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Detalles Bibliográficos
Autores principales: Özcan, Fedai, Köhrmann, Martin, Petros, Sirak, Goette, Andreas, Bramlage, Peter, Bommer, Martin, Brokmann, Jörg Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Medizin 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10160152/
https://www.ncbi.nlm.nih.gov/pubmed/36598518
http://dx.doi.org/10.1007/s00063-022-00982-w
Descripción
Sumario:Thrombotic thrombocytopenic purpura (TTP), which comprises thrombocytopenia, elevated lactate dehydrogenase levels, and anemia in the combination of organ involvement, is a rare but life-threatening condition associated with an extremely high lethality in the acute phase if left untreated. Using the example of a 49-year-old woman admitted to the hospital with unexplained abdominal symptoms and subfebrile temperatures, recommendations for the emergency situation are presented. Increased awareness of the disease and targeted further diagnostics with determination of the PLASMIC score or ADAMTS13 activity may lead directly to diagnosis of TTP; delayed diagnosis is usually associated with secondary complications.