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Squamous cell lung carcinoma with gastrointestinal metastasis: a case report and review of literature

Squamous cell lung carcinoma (LUSC) originates from squamous cells and has a high rate of metastasis and recurrence. The lack of effective genetic targets and specific therapies has resulted in a poor prognosis for patients with LUSC. Gastrointestinal metastasis of LUSC is a rare occurrence in clini...

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Autores principales: Li, Feifei, Liu, Yiqiang, Xu, Ke, Yao, Quan, Li, Qiang, Wu, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10160372/
https://www.ncbi.nlm.nih.gov/pubmed/37152036
http://dx.doi.org/10.3389/fonc.2023.1138871
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author Li, Feifei
Liu, Yiqiang
Xu, Ke
Yao, Quan
Li, Qiang
Wu, Hong
author_facet Li, Feifei
Liu, Yiqiang
Xu, Ke
Yao, Quan
Li, Qiang
Wu, Hong
author_sort Li, Feifei
collection PubMed
description Squamous cell lung carcinoma (LUSC) originates from squamous cells and has a high rate of metastasis and recurrence. The lack of effective genetic targets and specific therapies has resulted in a poor prognosis for patients with LUSC. Gastrointestinal metastasis of LUSC is a rare occurrence in clinical practice. Patients with gastrointestinal metastasis usually have worse overall survival and the process of diagnosis is more complicated than those with metastasis elsewhere. What’s more, there are no helpful guidelines for treating patients with a clinically confirmed diagnosis of gastrointestinal metastasis, which means the treatment method is limited. Here, we review the clinical features, diagnosis, and treatment of LUSC patients with gastrointestinal metastasis and report a rare case of LUSC accompanied by gastrointestinal metastasis. The patient was admitted to the hospital with coughing and hemoptysis. A tumor was found in his lung, and lesions were initially controlled with standard treatment. The patient’s tumor re-occurred again shortly for which treatment was lacking. Without effective treatment methods, the disease was difficult to control. Our learnings from the case demonstrate that LUSC metastasizes to secondary lymphoid organs of the gastrointestinal tract, usually with a poor prognosis.
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spelling pubmed-101603722023-05-06 Squamous cell lung carcinoma with gastrointestinal metastasis: a case report and review of literature Li, Feifei Liu, Yiqiang Xu, Ke Yao, Quan Li, Qiang Wu, Hong Front Oncol Oncology Squamous cell lung carcinoma (LUSC) originates from squamous cells and has a high rate of metastasis and recurrence. The lack of effective genetic targets and specific therapies has resulted in a poor prognosis for patients with LUSC. Gastrointestinal metastasis of LUSC is a rare occurrence in clinical practice. Patients with gastrointestinal metastasis usually have worse overall survival and the process of diagnosis is more complicated than those with metastasis elsewhere. What’s more, there are no helpful guidelines for treating patients with a clinically confirmed diagnosis of gastrointestinal metastasis, which means the treatment method is limited. Here, we review the clinical features, diagnosis, and treatment of LUSC patients with gastrointestinal metastasis and report a rare case of LUSC accompanied by gastrointestinal metastasis. The patient was admitted to the hospital with coughing and hemoptysis. A tumor was found in his lung, and lesions were initially controlled with standard treatment. The patient’s tumor re-occurred again shortly for which treatment was lacking. Without effective treatment methods, the disease was difficult to control. Our learnings from the case demonstrate that LUSC metastasizes to secondary lymphoid organs of the gastrointestinal tract, usually with a poor prognosis. Frontiers Media S.A. 2023-04-21 /pmc/articles/PMC10160372/ /pubmed/37152036 http://dx.doi.org/10.3389/fonc.2023.1138871 Text en Copyright © 2023 Li, Liu, Xu, Yao, Li and Wu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Li, Feifei
Liu, Yiqiang
Xu, Ke
Yao, Quan
Li, Qiang
Wu, Hong
Squamous cell lung carcinoma with gastrointestinal metastasis: a case report and review of literature
title Squamous cell lung carcinoma with gastrointestinal metastasis: a case report and review of literature
title_full Squamous cell lung carcinoma with gastrointestinal metastasis: a case report and review of literature
title_fullStr Squamous cell lung carcinoma with gastrointestinal metastasis: a case report and review of literature
title_full_unstemmed Squamous cell lung carcinoma with gastrointestinal metastasis: a case report and review of literature
title_short Squamous cell lung carcinoma with gastrointestinal metastasis: a case report and review of literature
title_sort squamous cell lung carcinoma with gastrointestinal metastasis: a case report and review of literature
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10160372/
https://www.ncbi.nlm.nih.gov/pubmed/37152036
http://dx.doi.org/10.3389/fonc.2023.1138871
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