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PET/MR versus PET/CT for locoregional staging of oropharyngeal squamous cell cancer

BACKGROUND: The value of fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) for TN staging in head and neck cancer (HNC) has been proven in numerous studies. A few studies have investigated the value of FDG-PET/magnetic resonance imaging (MRI) in the staging...

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Autores principales: Flygare, Lennart, Erdogan, Secil Telli, Söderkvist, Karin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10160406/
https://www.ncbi.nlm.nih.gov/pubmed/36464816
http://dx.doi.org/10.1177/02841851221140668
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author Flygare, Lennart
Erdogan, Secil Telli
Söderkvist, Karin
author_facet Flygare, Lennart
Erdogan, Secil Telli
Söderkvist, Karin
author_sort Flygare, Lennart
collection PubMed
description BACKGROUND: The value of fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) for TN staging in head and neck cancer (HNC) has been proven in numerous studies. A few studies have investigated the value of FDG-PET/magnetic resonance imaging (MRI) in the staging of HNC; the combined results indicate potential for FDG-PET/MRI, but the scientific evidence remains weak. PURPOSE: To compare performance of FDG-PET/CT and FDG-PET/MRI for locoregional staging in patients with oropharyngeal carcinomas. MATERIAL AND METHODS: Two radiologists independently of each other retrospectively reviewed primary pre-therapeutic FDG-PET/CT and FDG-PET/MRI examinations from 40 individuals with oropharyngeal carcinomas. TN stage and primary tumor size were noted. The results were compared between observers and modalities and against TN stage set at a multidisciplinary conference. RESULTS: For nodal staging, PET/MRI had slightly higher specificity and accuracy than PET/CT for the most experienced observer. Both methods demonstrated excellent sensitivity (≥ 0.97 and 1.00, respectively), as well as high negative predictive values (≥ 0.95 and 1.00, respectively). No significant differences were found for tumor staging or measurement of maximum tumor diameter. There was a weak agreement (κ = 0.35–0.49) between PET/CT and PET/MRI for T and N stages for both observers. Inter-observer agreement was higher for PET/MRI than for PET/CT, both for tumor staging (κ = 0.57 vs. 0.35) and nodal staging (κ = 0.69 vs. 0.55). The agreement between observers was comparable to the agreement between methods. CONCLUSION: PET/MRI may be a viable alternative to PET/CT for locoregional staging (TN staging) and assessment of maximal tumor diameter in oropharyngeal squamous cell cancer.
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spelling pubmed-101604062023-05-06 PET/MR versus PET/CT for locoregional staging of oropharyngeal squamous cell cancer Flygare, Lennart Erdogan, Secil Telli Söderkvist, Karin Acta Radiol Head and Neck Imaging BACKGROUND: The value of fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) for TN staging in head and neck cancer (HNC) has been proven in numerous studies. A few studies have investigated the value of FDG-PET/magnetic resonance imaging (MRI) in the staging of HNC; the combined results indicate potential for FDG-PET/MRI, but the scientific evidence remains weak. PURPOSE: To compare performance of FDG-PET/CT and FDG-PET/MRI for locoregional staging in patients with oropharyngeal carcinomas. MATERIAL AND METHODS: Two radiologists independently of each other retrospectively reviewed primary pre-therapeutic FDG-PET/CT and FDG-PET/MRI examinations from 40 individuals with oropharyngeal carcinomas. TN stage and primary tumor size were noted. The results were compared between observers and modalities and against TN stage set at a multidisciplinary conference. RESULTS: For nodal staging, PET/MRI had slightly higher specificity and accuracy than PET/CT for the most experienced observer. Both methods demonstrated excellent sensitivity (≥ 0.97 and 1.00, respectively), as well as high negative predictive values (≥ 0.95 and 1.00, respectively). No significant differences were found for tumor staging or measurement of maximum tumor diameter. There was a weak agreement (κ = 0.35–0.49) between PET/CT and PET/MRI for T and N stages for both observers. Inter-observer agreement was higher for PET/MRI than for PET/CT, both for tumor staging (κ = 0.57 vs. 0.35) and nodal staging (κ = 0.69 vs. 0.55). The agreement between observers was comparable to the agreement between methods. CONCLUSION: PET/MRI may be a viable alternative to PET/CT for locoregional staging (TN staging) and assessment of maximal tumor diameter in oropharyngeal squamous cell cancer. SAGE Publications 2022-12-04 2023-05 /pmc/articles/PMC10160406/ /pubmed/36464816 http://dx.doi.org/10.1177/02841851221140668 Text en © The Foundation Acta Radiologica 2022 https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Head and Neck Imaging
Flygare, Lennart
Erdogan, Secil Telli
Söderkvist, Karin
PET/MR versus PET/CT for locoregional staging of oropharyngeal squamous cell cancer
title PET/MR versus PET/CT for locoregional staging of oropharyngeal squamous cell cancer
title_full PET/MR versus PET/CT for locoregional staging of oropharyngeal squamous cell cancer
title_fullStr PET/MR versus PET/CT for locoregional staging of oropharyngeal squamous cell cancer
title_full_unstemmed PET/MR versus PET/CT for locoregional staging of oropharyngeal squamous cell cancer
title_short PET/MR versus PET/CT for locoregional staging of oropharyngeal squamous cell cancer
title_sort pet/mr versus pet/ct for locoregional staging of oropharyngeal squamous cell cancer
topic Head and Neck Imaging
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10160406/
https://www.ncbi.nlm.nih.gov/pubmed/36464816
http://dx.doi.org/10.1177/02841851221140668
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