Trimethylamine-N-oxide: a potential biomarker and therapeutic target in ischemic stroke

Ischemic stroke is by far the most common cerebrovascular disease and a major burden to the global economy and public health. Trimethylamine-N-oxide (TMAO), a small molecule compound produced by the metabolism of intestinal microorganisms, is reportedly associated with the risk of stroke, as well as...

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Autores principales: Liu, Yuan, Qu, Juan, Xu, Junjie, Gu, Aiming, Deng, Dezhi, Jia, Xiaodan, Wang, Baoxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10160411/
https://www.ncbi.nlm.nih.gov/pubmed/37153682
http://dx.doi.org/10.3389/fneur.2023.1156879
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author Liu, Yuan
Qu, Juan
Xu, Junjie
Gu, Aiming
Deng, Dezhi
Jia, Xiaodan
Wang, Baoxiang
author_facet Liu, Yuan
Qu, Juan
Xu, Junjie
Gu, Aiming
Deng, Dezhi
Jia, Xiaodan
Wang, Baoxiang
author_sort Liu, Yuan
collection PubMed
description Ischemic stroke is by far the most common cerebrovascular disease and a major burden to the global economy and public health. Trimethylamine-N-oxide (TMAO), a small molecule compound produced by the metabolism of intestinal microorganisms, is reportedly associated with the risk of stroke, as well as the severity and prognosis of stroke; however, this conclusion remains contentious. This article reviews the production of TMAO, TMAO’s relationship with different etiological types of ischemic stroke, and the possibility of reducing TMAO levels to improve the prognosis of ischemic stroke.
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spelling pubmed-101604112023-05-06 Trimethylamine-N-oxide: a potential biomarker and therapeutic target in ischemic stroke Liu, Yuan Qu, Juan Xu, Junjie Gu, Aiming Deng, Dezhi Jia, Xiaodan Wang, Baoxiang Front Neurol Neurology Ischemic stroke is by far the most common cerebrovascular disease and a major burden to the global economy and public health. Trimethylamine-N-oxide (TMAO), a small molecule compound produced by the metabolism of intestinal microorganisms, is reportedly associated with the risk of stroke, as well as the severity and prognosis of stroke; however, this conclusion remains contentious. This article reviews the production of TMAO, TMAO’s relationship with different etiological types of ischemic stroke, and the possibility of reducing TMAO levels to improve the prognosis of ischemic stroke. Frontiers Media S.A. 2023-04-21 /pmc/articles/PMC10160411/ /pubmed/37153682 http://dx.doi.org/10.3389/fneur.2023.1156879 Text en Copyright © 2023 Liu, Qu, Xu, Gu, Deng, Jia and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Liu, Yuan
Qu, Juan
Xu, Junjie
Gu, Aiming
Deng, Dezhi
Jia, Xiaodan
Wang, Baoxiang
Trimethylamine-N-oxide: a potential biomarker and therapeutic target in ischemic stroke
title Trimethylamine-N-oxide: a potential biomarker and therapeutic target in ischemic stroke
title_full Trimethylamine-N-oxide: a potential biomarker and therapeutic target in ischemic stroke
title_fullStr Trimethylamine-N-oxide: a potential biomarker and therapeutic target in ischemic stroke
title_full_unstemmed Trimethylamine-N-oxide: a potential biomarker and therapeutic target in ischemic stroke
title_short Trimethylamine-N-oxide: a potential biomarker and therapeutic target in ischemic stroke
title_sort trimethylamine-n-oxide: a potential biomarker and therapeutic target in ischemic stroke
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10160411/
https://www.ncbi.nlm.nih.gov/pubmed/37153682
http://dx.doi.org/10.3389/fneur.2023.1156879
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