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Endoplasmic reticulum stress and ubiquitin-proteasome system impairment in natural scrapie

Chronic accumulation of misfolded proteins such as PrP(Sc) can alter the endoplasmic reticulum homeostasis triggering the unfolded protein response (UPR). In this pathogenic event, the molecular chaperones play an important role. Several reports in humans and animals have suggested that neurodegener...

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Detalles Bibliográficos
Autores principales:	Lozada Ortiz, Jenny, Betancor, Marina, Pérez Lázaro, Sonia, Bolea, Rosa, Badiola, Juan J., Otero, Alicia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Molecular Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10160437/ https://www.ncbi.nlm.nih.gov/pubmed/37152434 http://dx.doi.org/10.3389/fnmol.2023.1175364

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