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The emerging roles of long non-coding RNA in host immune response and intracellular bacterial infections
The long non-coding RNAs (lncRNAs) are evolutionarily conserved classes of non-coding regulatory transcripts of > 200 nucleotides in length. They modulate several transcriptional and post-transcriptional events in the organism. Depending on their cellular localization and interactions, they regul...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10160451/ https://www.ncbi.nlm.nih.gov/pubmed/37153158 http://dx.doi.org/10.3389/fcimb.2023.1160198 |
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author | Arunima, Aryashree van Schaik, Erin J. Samuel, James E. |
author_facet | Arunima, Aryashree van Schaik, Erin J. Samuel, James E. |
author_sort | Arunima, Aryashree |
collection | PubMed |
description | The long non-coding RNAs (lncRNAs) are evolutionarily conserved classes of non-coding regulatory transcripts of > 200 nucleotides in length. They modulate several transcriptional and post-transcriptional events in the organism. Depending on their cellular localization and interactions, they regulate chromatin function and assembly; and alter the stability and translation of cytoplasmic mRNAs. Although their proposed range of functionality remains controversial, there is increasing research evidence that lncRNAs play a regulatory role in the activation, differentiation and development of immune signaling cascades; microbiome development; and in diseases such as neuronal and cardiovascular disorders; cancer; and pathogenic infections. This review discusses the functional roles of different lncRNAs in regulation of host immune responses, signaling pathways during host-microbe interaction and infection caused by obligate intracellular bacterial pathogens. The study of lncRNAs is assuming significance as it could be exploited for development of alternative therapeutic strategies for the treatment of severe and chronic pathogenic infections caused by Mycobacterium, Chlamydia and Rickettsia infections, as well as commensal colonization. Finally, this review summarizes the translational potential of lncRNA research in development of diagnostic and prognostic tools for human diseases. |
format | Online Article Text |
id | pubmed-10160451 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-101604512023-05-06 The emerging roles of long non-coding RNA in host immune response and intracellular bacterial infections Arunima, Aryashree van Schaik, Erin J. Samuel, James E. Front Cell Infect Microbiol Cellular and Infection Microbiology The long non-coding RNAs (lncRNAs) are evolutionarily conserved classes of non-coding regulatory transcripts of > 200 nucleotides in length. They modulate several transcriptional and post-transcriptional events in the organism. Depending on their cellular localization and interactions, they regulate chromatin function and assembly; and alter the stability and translation of cytoplasmic mRNAs. Although their proposed range of functionality remains controversial, there is increasing research evidence that lncRNAs play a regulatory role in the activation, differentiation and development of immune signaling cascades; microbiome development; and in diseases such as neuronal and cardiovascular disorders; cancer; and pathogenic infections. This review discusses the functional roles of different lncRNAs in regulation of host immune responses, signaling pathways during host-microbe interaction and infection caused by obligate intracellular bacterial pathogens. The study of lncRNAs is assuming significance as it could be exploited for development of alternative therapeutic strategies for the treatment of severe and chronic pathogenic infections caused by Mycobacterium, Chlamydia and Rickettsia infections, as well as commensal colonization. Finally, this review summarizes the translational potential of lncRNA research in development of diagnostic and prognostic tools for human diseases. Frontiers Media S.A. 2023-04-21 /pmc/articles/PMC10160451/ /pubmed/37153158 http://dx.doi.org/10.3389/fcimb.2023.1160198 Text en Copyright © 2023 Arunima, van Schaik and Samuel https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cellular and Infection Microbiology Arunima, Aryashree van Schaik, Erin J. Samuel, James E. The emerging roles of long non-coding RNA in host immune response and intracellular bacterial infections |
title | The emerging roles of long non-coding RNA in host immune response and intracellular bacterial infections |
title_full | The emerging roles of long non-coding RNA in host immune response and intracellular bacterial infections |
title_fullStr | The emerging roles of long non-coding RNA in host immune response and intracellular bacterial infections |
title_full_unstemmed | The emerging roles of long non-coding RNA in host immune response and intracellular bacterial infections |
title_short | The emerging roles of long non-coding RNA in host immune response and intracellular bacterial infections |
title_sort | emerging roles of long non-coding rna in host immune response and intracellular bacterial infections |
topic | Cellular and Infection Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10160451/ https://www.ncbi.nlm.nih.gov/pubmed/37153158 http://dx.doi.org/10.3389/fcimb.2023.1160198 |
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