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Etiology of viral induced acute liver failure and defensins as potential therapeutic agents in ALF treatment

Acute liver failure (ALF) is a rare and severe disease, which, despite continuous advances in medicine, is still characterized by high mortality (65-85%). Very often, a liver transplant is the only effective treatment for ALF. Despite the implementation of prophylactic vaccinations in the world, the...

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Autores principales: Hrynkiewicz, Rafał, Niedźwiedzka-Rystwej, Paulina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10160486/
https://www.ncbi.nlm.nih.gov/pubmed/37153560
http://dx.doi.org/10.3389/fimmu.2023.1153528
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author Hrynkiewicz, Rafał
Niedźwiedzka-Rystwej, Paulina
author_facet Hrynkiewicz, Rafał
Niedźwiedzka-Rystwej, Paulina
author_sort Hrynkiewicz, Rafał
collection PubMed
description Acute liver failure (ALF) is a rare and severe disease, which, despite continuous advances in medicine, is still characterized by high mortality (65-85%). Very often, a liver transplant is the only effective treatment for ALF. Despite the implementation of prophylactic vaccinations in the world, the viral background of ALF is still a problem and leads to many deaths. Depending on the cause of ALF, it is sometimes possible to reverse this condition with appropriate therapies, which is why the search for effective antiviral agents seems to be a very desirable direction of research. Defensins, which are our natural antimicrobial peptides, have a very high potential to be used as therapeutic agents for infectious liver diseases. Previous studies on the expression of human defensins have shown that increased expression of human α and β-defensins in HCV and HBV infections is associated with a better response to treatment. Unfortunately, conducting clinical trials for ALF is very difficult due to the severity of the disease and the low incidence, therefore animal models are important for the development of new therapeutic strategies. One of the best animal models that has real reference to research on acute liver failure (ALF) is rabbit hemorrhagic disease in rabbits caused by the Lagovirus europaeus virus. So far, there have been no studies on the potential of defensins in rabbits infected with Lagovirus europaeus virus.
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spelling pubmed-101604862023-05-06 Etiology of viral induced acute liver failure and defensins as potential therapeutic agents in ALF treatment Hrynkiewicz, Rafał Niedźwiedzka-Rystwej, Paulina Front Immunol Immunology Acute liver failure (ALF) is a rare and severe disease, which, despite continuous advances in medicine, is still characterized by high mortality (65-85%). Very often, a liver transplant is the only effective treatment for ALF. Despite the implementation of prophylactic vaccinations in the world, the viral background of ALF is still a problem and leads to many deaths. Depending on the cause of ALF, it is sometimes possible to reverse this condition with appropriate therapies, which is why the search for effective antiviral agents seems to be a very desirable direction of research. Defensins, which are our natural antimicrobial peptides, have a very high potential to be used as therapeutic agents for infectious liver diseases. Previous studies on the expression of human defensins have shown that increased expression of human α and β-defensins in HCV and HBV infections is associated with a better response to treatment. Unfortunately, conducting clinical trials for ALF is very difficult due to the severity of the disease and the low incidence, therefore animal models are important for the development of new therapeutic strategies. One of the best animal models that has real reference to research on acute liver failure (ALF) is rabbit hemorrhagic disease in rabbits caused by the Lagovirus europaeus virus. So far, there have been no studies on the potential of defensins in rabbits infected with Lagovirus europaeus virus. Frontiers Media S.A. 2023-04-21 /pmc/articles/PMC10160486/ /pubmed/37153560 http://dx.doi.org/10.3389/fimmu.2023.1153528 Text en Copyright © 2023 Hrynkiewicz and Niedźwiedzka-Rystwej https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Hrynkiewicz, Rafał
Niedźwiedzka-Rystwej, Paulina
Etiology of viral induced acute liver failure and defensins as potential therapeutic agents in ALF treatment
title Etiology of viral induced acute liver failure and defensins as potential therapeutic agents in ALF treatment
title_full Etiology of viral induced acute liver failure and defensins as potential therapeutic agents in ALF treatment
title_fullStr Etiology of viral induced acute liver failure and defensins as potential therapeutic agents in ALF treatment
title_full_unstemmed Etiology of viral induced acute liver failure and defensins as potential therapeutic agents in ALF treatment
title_short Etiology of viral induced acute liver failure and defensins as potential therapeutic agents in ALF treatment
title_sort etiology of viral induced acute liver failure and defensins as potential therapeutic agents in alf treatment
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10160486/
https://www.ncbi.nlm.nih.gov/pubmed/37153560
http://dx.doi.org/10.3389/fimmu.2023.1153528
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