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Altered subgroups of regulatory T cells in patients with primary Sjögren's syndrome
Primary Sjögren syndrome (pSS) is a systemic autoimmune inflammatory disease. Up to now, the role of regulatory T cells (Tregs) and their subgroups in pSS is still in controversial. In this study we tried to elucidate the roles of Tregs and its subgroups in pSS. Total 43 pSS patients and 23 health p...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10160513/ https://www.ncbi.nlm.nih.gov/pubmed/37153426 http://dx.doi.org/10.1016/j.heliyon.2023.e15565 |
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author | Lin, Jing-Chi Pan, Kuo-Li Li, Cheng-Feng Lee, Kam-Fai Lin, Kuan-Yu Lin, Ko-Ming Lin, Chun-Yen |
author_facet | Lin, Jing-Chi Pan, Kuo-Li Li, Cheng-Feng Lee, Kam-Fai Lin, Kuan-Yu Lin, Ko-Ming Lin, Chun-Yen |
author_sort | Lin, Jing-Chi |
collection | PubMed |
description | Primary Sjögren syndrome (pSS) is a systemic autoimmune inflammatory disease. Up to now, the role of regulatory T cells (Tregs) and their subgroups in pSS is still in controversial. In this study we tried to elucidate the roles of Tregs and its subgroups in pSS. Total 43 pSS patients and 23 health persons as control were enrolled in this study. We grouped the pSS patients according to the anti-SSa/SSb and the EULAR Sjögren's syndrome disease activity index (ESSDAI). Among the 43 pSS patients, 14 patients were followed after treatment. The percentage of rTregs (resting Treg cells) among Tregs was increased in the pSS group, and decreased after treatment. In the high disease activity subpopulation (ESSDAI ≥ 5), the percentage of rTregs among Tregs decreased after treatment. On the contrary, the percentage of aTregs (activated Treg cells) increased after treatment. It was in an inverse correlation between the percentage of aTreg and rTreg in pSS patients. The Tregs are co-cultured with responder T cells. Tregs from pSS patients showed poorer proliferation inhibitory function. Our results show that the percentages of Tregs and their subgroups altered in pSS patients. The percentage of aTreg and the percentage of rTreg have an inverse correlation in pSS patients. Compared to the control group, the percentage of rTregs among Tregs was increased in the pSS patients and decreased after the treatment. Our study also showed that The Tregs from pSS patients may have poorer inhibitory functions. |
format | Online Article Text |
id | pubmed-10160513 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-101605132023-05-06 Altered subgroups of regulatory T cells in patients with primary Sjögren's syndrome Lin, Jing-Chi Pan, Kuo-Li Li, Cheng-Feng Lee, Kam-Fai Lin, Kuan-Yu Lin, Ko-Ming Lin, Chun-Yen Heliyon Research Article Primary Sjögren syndrome (pSS) is a systemic autoimmune inflammatory disease. Up to now, the role of regulatory T cells (Tregs) and their subgroups in pSS is still in controversial. In this study we tried to elucidate the roles of Tregs and its subgroups in pSS. Total 43 pSS patients and 23 health persons as control were enrolled in this study. We grouped the pSS patients according to the anti-SSa/SSb and the EULAR Sjögren's syndrome disease activity index (ESSDAI). Among the 43 pSS patients, 14 patients were followed after treatment. The percentage of rTregs (resting Treg cells) among Tregs was increased in the pSS group, and decreased after treatment. In the high disease activity subpopulation (ESSDAI ≥ 5), the percentage of rTregs among Tregs decreased after treatment. On the contrary, the percentage of aTregs (activated Treg cells) increased after treatment. It was in an inverse correlation between the percentage of aTreg and rTreg in pSS patients. The Tregs are co-cultured with responder T cells. Tregs from pSS patients showed poorer proliferation inhibitory function. Our results show that the percentages of Tregs and their subgroups altered in pSS patients. The percentage of aTreg and the percentage of rTreg have an inverse correlation in pSS patients. Compared to the control group, the percentage of rTregs among Tregs was increased in the pSS patients and decreased after the treatment. Our study also showed that The Tregs from pSS patients may have poorer inhibitory functions. Elsevier 2023-04-18 /pmc/articles/PMC10160513/ /pubmed/37153426 http://dx.doi.org/10.1016/j.heliyon.2023.e15565 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Research Article Lin, Jing-Chi Pan, Kuo-Li Li, Cheng-Feng Lee, Kam-Fai Lin, Kuan-Yu Lin, Ko-Ming Lin, Chun-Yen Altered subgroups of regulatory T cells in patients with primary Sjögren's syndrome |
title | Altered subgroups of regulatory T cells in patients with primary Sjögren's syndrome |
title_full | Altered subgroups of regulatory T cells in patients with primary Sjögren's syndrome |
title_fullStr | Altered subgroups of regulatory T cells in patients with primary Sjögren's syndrome |
title_full_unstemmed | Altered subgroups of regulatory T cells in patients with primary Sjögren's syndrome |
title_short | Altered subgroups of regulatory T cells in patients with primary Sjögren's syndrome |
title_sort | altered subgroups of regulatory t cells in patients with primary sjögren's syndrome |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10160513/ https://www.ncbi.nlm.nih.gov/pubmed/37153426 http://dx.doi.org/10.1016/j.heliyon.2023.e15565 |
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