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Altered subgroups of regulatory T cells in patients with primary Sjögren's syndrome

Primary Sjögren syndrome (pSS) is a systemic autoimmune inflammatory disease. Up to now, the role of regulatory T cells (Tregs) and their subgroups in pSS is still in controversial. In this study we tried to elucidate the roles of Tregs and its subgroups in pSS. Total 43 pSS patients and 23 health p...

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Autores principales: Lin, Jing-Chi, Pan, Kuo-Li, Li, Cheng-Feng, Lee, Kam-Fai, Lin, Kuan-Yu, Lin, Ko-Ming, Lin, Chun-Yen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10160513/
https://www.ncbi.nlm.nih.gov/pubmed/37153426
http://dx.doi.org/10.1016/j.heliyon.2023.e15565
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author Lin, Jing-Chi
Pan, Kuo-Li
Li, Cheng-Feng
Lee, Kam-Fai
Lin, Kuan-Yu
Lin, Ko-Ming
Lin, Chun-Yen
author_facet Lin, Jing-Chi
Pan, Kuo-Li
Li, Cheng-Feng
Lee, Kam-Fai
Lin, Kuan-Yu
Lin, Ko-Ming
Lin, Chun-Yen
author_sort Lin, Jing-Chi
collection PubMed
description Primary Sjögren syndrome (pSS) is a systemic autoimmune inflammatory disease. Up to now, the role of regulatory T cells (Tregs) and their subgroups in pSS is still in controversial. In this study we tried to elucidate the roles of Tregs and its subgroups in pSS. Total 43 pSS patients and 23 health persons as control were enrolled in this study. We grouped the pSS patients according to the anti-SSa/SSb and the EULAR Sjögren's syndrome disease activity index (ESSDAI). Among the 43 pSS patients, 14 patients were followed after treatment. The percentage of rTregs (resting Treg cells) among Tregs was increased in the pSS group, and decreased after treatment. In the high disease activity subpopulation (ESSDAI ≥ 5), the percentage of rTregs among Tregs decreased after treatment. On the contrary, the percentage of aTregs (activated Treg cells) increased after treatment. It was in an inverse correlation between the percentage of aTreg and rTreg in pSS patients. The Tregs are co-cultured with responder T cells. Tregs from pSS patients showed poorer proliferation inhibitory function. Our results show that the percentages of Tregs and their subgroups altered in pSS patients. The percentage of aTreg and the percentage of rTreg have an inverse correlation in pSS patients. Compared to the control group, the percentage of rTregs among Tregs was increased in the pSS patients and decreased after the treatment. Our study also showed that The Tregs from pSS patients may have poorer inhibitory functions.
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spelling pubmed-101605132023-05-06 Altered subgroups of regulatory T cells in patients with primary Sjögren's syndrome Lin, Jing-Chi Pan, Kuo-Li Li, Cheng-Feng Lee, Kam-Fai Lin, Kuan-Yu Lin, Ko-Ming Lin, Chun-Yen Heliyon Research Article Primary Sjögren syndrome (pSS) is a systemic autoimmune inflammatory disease. Up to now, the role of regulatory T cells (Tregs) and their subgroups in pSS is still in controversial. In this study we tried to elucidate the roles of Tregs and its subgroups in pSS. Total 43 pSS patients and 23 health persons as control were enrolled in this study. We grouped the pSS patients according to the anti-SSa/SSb and the EULAR Sjögren's syndrome disease activity index (ESSDAI). Among the 43 pSS patients, 14 patients were followed after treatment. The percentage of rTregs (resting Treg cells) among Tregs was increased in the pSS group, and decreased after treatment. In the high disease activity subpopulation (ESSDAI ≥ 5), the percentage of rTregs among Tregs decreased after treatment. On the contrary, the percentage of aTregs (activated Treg cells) increased after treatment. It was in an inverse correlation between the percentage of aTreg and rTreg in pSS patients. The Tregs are co-cultured with responder T cells. Tregs from pSS patients showed poorer proliferation inhibitory function. Our results show that the percentages of Tregs and their subgroups altered in pSS patients. The percentage of aTreg and the percentage of rTreg have an inverse correlation in pSS patients. Compared to the control group, the percentage of rTregs among Tregs was increased in the pSS patients and decreased after the treatment. Our study also showed that The Tregs from pSS patients may have poorer inhibitory functions. Elsevier 2023-04-18 /pmc/articles/PMC10160513/ /pubmed/37153426 http://dx.doi.org/10.1016/j.heliyon.2023.e15565 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Lin, Jing-Chi
Pan, Kuo-Li
Li, Cheng-Feng
Lee, Kam-Fai
Lin, Kuan-Yu
Lin, Ko-Ming
Lin, Chun-Yen
Altered subgroups of regulatory T cells in patients with primary Sjögren's syndrome
title Altered subgroups of regulatory T cells in patients with primary Sjögren's syndrome
title_full Altered subgroups of regulatory T cells in patients with primary Sjögren's syndrome
title_fullStr Altered subgroups of regulatory T cells in patients with primary Sjögren's syndrome
title_full_unstemmed Altered subgroups of regulatory T cells in patients with primary Sjögren's syndrome
title_short Altered subgroups of regulatory T cells in patients with primary Sjögren's syndrome
title_sort altered subgroups of regulatory t cells in patients with primary sjögren's syndrome
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10160513/
https://www.ncbi.nlm.nih.gov/pubmed/37153426
http://dx.doi.org/10.1016/j.heliyon.2023.e15565
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