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Three Cases of Gouty Tophus in the Foot Treated by Resection

We encountered three cases of gouty tophus in the foot that required resection. All patients were male and aged 44-68 years at the time of surgery. The lesions were located on the great toe, second toe, and lateral malleolus and were causing ulceration and destruction of the joints. One patient had...

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Autores principales: Shiozaki, Taro, Kimura, Tadashi, Saito, Mitsuru, Kubota, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10160552/
https://www.ncbi.nlm.nih.gov/pubmed/37153285
http://dx.doi.org/10.7759/cureus.37144
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author Shiozaki, Taro
Kimura, Tadashi
Saito, Mitsuru
Kubota, Makoto
author_facet Shiozaki, Taro
Kimura, Tadashi
Saito, Mitsuru
Kubota, Makoto
author_sort Shiozaki, Taro
collection PubMed
description We encountered three cases of gouty tophus in the foot that required resection. All patients were male and aged 44-68 years at the time of surgery. The lesions were located on the great toe, second toe, and lateral malleolus and were causing ulceration and destruction of the joints. One patient had normal uric acid levels, and another patient had hyperuricemia but no history of attacks and no significant inflammatory symptoms around the gouty tophus, which was attributed to the physical containment of uric acid crystals by the gouty tophus. Given that the crystals were adherent to the surrounding fibrous tissue and cartilage surface, we resected them as far as possible to reduce the total amount of crystals and treated the remaining crystals with uric acid-lowering therapy. There were no complications at the time of surgery. The swelling and bone destruction subsided with continued medical treatment, resulting in significant improvement in quality of life. Patients with gouty tophus should be treated aggressively with medication and monitored to prevent severe joint destruction and ulceration. Excision of the nodule should be considered in cases of exacerbation.
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spelling pubmed-101605522023-05-06 Three Cases of Gouty Tophus in the Foot Treated by Resection Shiozaki, Taro Kimura, Tadashi Saito, Mitsuru Kubota, Makoto Cureus Orthopedics We encountered three cases of gouty tophus in the foot that required resection. All patients were male and aged 44-68 years at the time of surgery. The lesions were located on the great toe, second toe, and lateral malleolus and were causing ulceration and destruction of the joints. One patient had normal uric acid levels, and another patient had hyperuricemia but no history of attacks and no significant inflammatory symptoms around the gouty tophus, which was attributed to the physical containment of uric acid crystals by the gouty tophus. Given that the crystals were adherent to the surrounding fibrous tissue and cartilage surface, we resected them as far as possible to reduce the total amount of crystals and treated the remaining crystals with uric acid-lowering therapy. There were no complications at the time of surgery. The swelling and bone destruction subsided with continued medical treatment, resulting in significant improvement in quality of life. Patients with gouty tophus should be treated aggressively with medication and monitored to prevent severe joint destruction and ulceration. Excision of the nodule should be considered in cases of exacerbation. Cureus 2023-04-04 /pmc/articles/PMC10160552/ /pubmed/37153285 http://dx.doi.org/10.7759/cureus.37144 Text en Copyright © 2023, Shiozaki et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Orthopedics
Shiozaki, Taro
Kimura, Tadashi
Saito, Mitsuru
Kubota, Makoto
Three Cases of Gouty Tophus in the Foot Treated by Resection
title Three Cases of Gouty Tophus in the Foot Treated by Resection
title_full Three Cases of Gouty Tophus in the Foot Treated by Resection
title_fullStr Three Cases of Gouty Tophus in the Foot Treated by Resection
title_full_unstemmed Three Cases of Gouty Tophus in the Foot Treated by Resection
title_short Three Cases of Gouty Tophus in the Foot Treated by Resection
title_sort three cases of gouty tophus in the foot treated by resection
topic Orthopedics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10160552/
https://www.ncbi.nlm.nih.gov/pubmed/37153285
http://dx.doi.org/10.7759/cureus.37144
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