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Circulating metabolites and depression: a bidirectional Mendelian randomization

BACKGROUND: Studies have shown an association between depression and circulating metabolites, but the causal relationship between them has not been elucidated. The purpose of this study was to elucidate the causal relationship between circulating metabolites and depression and to explore the role of...

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Autores principales: Dong, Yankai, Zou, Zengxiao, Deng, Pin, Fan, Xiaoping, Li, Chunlin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10160621/
https://www.ncbi.nlm.nih.gov/pubmed/37152596
http://dx.doi.org/10.3389/fnins.2023.1146613
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author Dong, Yankai
Zou, Zengxiao
Deng, Pin
Fan, Xiaoping
Li, Chunlin
author_facet Dong, Yankai
Zou, Zengxiao
Deng, Pin
Fan, Xiaoping
Li, Chunlin
author_sort Dong, Yankai
collection PubMed
description BACKGROUND: Studies have shown an association between depression and circulating metabolites, but the causal relationship between them has not been elucidated. The purpose of this study was to elucidate the causal relationship between circulating metabolites and depression and to explore the role of circulating metabolites in depression. METHODS: In this study, the top single-nucleotide polymorphisms (SNPs) associated with circulating metabolites (n = 24,925) and depression (n = 322,580) were obtained based on the publicly available genome-wide association study using two-sample Mendelian randomization (MR). SNP estimates were summarized through inverse variance weighted, MR Egger, weighted median, MR pleiotropy residual sum and outlier, and “leave-one-out” methods. RESULTS: Apolipoprotein A-I (OR 0.990, 95% CI 981–0.999) and glutamine (OR 0.985, 95% CI 0.972–0.997) had protective causal effects on depression, whereas acetoacetate (OR 1.021, 95% CI 1.009–1.034), glycoproteins (OR 1.005, 95% CI 1.000–1.009), isoleucine (OR 1.013, 95% CI 1.002–1.024), and urea (OR 1.020, 95% CI 1.000–1.039) had an anti-protective effect on depression. Reversed MR showed no effect of depression on the seven circulating metabolites. CONCLUSION: In this study, MR analysis showed that apolipoprotein A-I and glutamine had a protective effect on depression, and acetoacetate, glycoprotein, isoleucine, glucose, and urea may be risk factors for depression. Therefore, further research must be conducted to translate the findings into practice.
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spelling pubmed-101606212023-05-06 Circulating metabolites and depression: a bidirectional Mendelian randomization Dong, Yankai Zou, Zengxiao Deng, Pin Fan, Xiaoping Li, Chunlin Front Neurosci Neuroscience BACKGROUND: Studies have shown an association between depression and circulating metabolites, but the causal relationship between them has not been elucidated. The purpose of this study was to elucidate the causal relationship between circulating metabolites and depression and to explore the role of circulating metabolites in depression. METHODS: In this study, the top single-nucleotide polymorphisms (SNPs) associated with circulating metabolites (n = 24,925) and depression (n = 322,580) were obtained based on the publicly available genome-wide association study using two-sample Mendelian randomization (MR). SNP estimates were summarized through inverse variance weighted, MR Egger, weighted median, MR pleiotropy residual sum and outlier, and “leave-one-out” methods. RESULTS: Apolipoprotein A-I (OR 0.990, 95% CI 981–0.999) and glutamine (OR 0.985, 95% CI 0.972–0.997) had protective causal effects on depression, whereas acetoacetate (OR 1.021, 95% CI 1.009–1.034), glycoproteins (OR 1.005, 95% CI 1.000–1.009), isoleucine (OR 1.013, 95% CI 1.002–1.024), and urea (OR 1.020, 95% CI 1.000–1.039) had an anti-protective effect on depression. Reversed MR showed no effect of depression on the seven circulating metabolites. CONCLUSION: In this study, MR analysis showed that apolipoprotein A-I and glutamine had a protective effect on depression, and acetoacetate, glycoprotein, isoleucine, glucose, and urea may be risk factors for depression. Therefore, further research must be conducted to translate the findings into practice. Frontiers Media S.A. 2023-04-21 /pmc/articles/PMC10160621/ /pubmed/37152596 http://dx.doi.org/10.3389/fnins.2023.1146613 Text en Copyright © 2023 Dong, Zou, Deng, Fan and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Dong, Yankai
Zou, Zengxiao
Deng, Pin
Fan, Xiaoping
Li, Chunlin
Circulating metabolites and depression: a bidirectional Mendelian randomization
title Circulating metabolites and depression: a bidirectional Mendelian randomization
title_full Circulating metabolites and depression: a bidirectional Mendelian randomization
title_fullStr Circulating metabolites and depression: a bidirectional Mendelian randomization
title_full_unstemmed Circulating metabolites and depression: a bidirectional Mendelian randomization
title_short Circulating metabolites and depression: a bidirectional Mendelian randomization
title_sort circulating metabolites and depression: a bidirectional mendelian randomization
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10160621/
https://www.ncbi.nlm.nih.gov/pubmed/37152596
http://dx.doi.org/10.3389/fnins.2023.1146613
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