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The cyclic guanosine monophosphate synthase-stimulator of interferon genes pathway as a potential target for tumor immunotherapy

Cyclic guanosine monophosphate–adenosine monophosphate (cGAMP) synthase (cGAS) detects infections or tissue damage by binding to microbial or self-DNA in the cytoplasm. Upon binding DNA, cGAS produces cGAMP that binds to and activates the adaptor protein stimulator of interferon genes (STING), which...

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Detalles Bibliográficos
Autores principales:	Chen, Rui, Liu, Mingxia, Jiang, Quanhong, Meng, Xiangbo, Wei, Junmin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10160662/ https://www.ncbi.nlm.nih.gov/pubmed/37153627 http://dx.doi.org/10.3389/fimmu.2023.1121603

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