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Long Covid as an Indication for Heart Transplantation and Its Characteristics

BACKGROUND: The post–acute cardiovascular manifestations of COVID-19, known as long COVID, have yet to be comprehensively characterized. There is also an increased risk of heart failure in individuals without cardiovascular disease before SARS-CoV-2 infection. The literature lacks information regard...

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Autores principales: Rossi Neto, Joao Manoel, Rossi, Raphael Machado, Wolf, Plinio Jose Whitaker, De Mello, Victor Bemfica, Dantas, Daniel Chagas, Santos, Carolina Casadei Dos, Finger, Marco Aurelio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10160848/
https://www.ncbi.nlm.nih.gov/pubmed/37150660
http://dx.doi.org/10.1016/j.transproceed.2023.03.071
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author Rossi Neto, Joao Manoel
Rossi, Raphael Machado
Wolf, Plinio Jose Whitaker
De Mello, Victor Bemfica
Dantas, Daniel Chagas
Santos, Carolina Casadei Dos
Finger, Marco Aurelio
author_facet Rossi Neto, Joao Manoel
Rossi, Raphael Machado
Wolf, Plinio Jose Whitaker
De Mello, Victor Bemfica
Dantas, Daniel Chagas
Santos, Carolina Casadei Dos
Finger, Marco Aurelio
author_sort Rossi Neto, Joao Manoel
collection PubMed
description BACKGROUND: The post–acute cardiovascular manifestations of COVID-19, known as long COVID, have yet to be comprehensively characterized. There is also an increased risk of heart failure in individuals without cardiovascular disease before SARS-CoV-2 infection. The literature lacks information regarding the characteristics of patients with long COVID who developed advanced heart failure refractory to guideline-directed medical therapy. METHODS: We describe the characteristics of patients with long COVID (LC) who were listed for heart transplantation. The study population comprised 45 patients listed for heart transplantation, divided into 2 groups: patients with etiologies other than LC (n = 41) and patients with LC (n = 4) between January 2020 and March 2022. The endpoint of this study was the description of the characteristics of each group. RESULTS: The average duration of hospitalization after the acute infectious episode with SARS-CoV-2 was 150 ± 113 days, and all patients were hospitalized in New York Heart Association class IV. All LC patients were oligosymptomatic in the initial infection, did not require hospitalization in the acute phase, had a lower ejection fraction, used more intra-aortic balloon pumps, had lower pulmonary vascular resistance, and fewer comorbidities compared with other etiologies, suggesting a clinical feature compatible with low cardiac output rather than congestion. CONCLUSIONS: This study is an early investigation of patients listed for heart transplantation due to a complex syndrome of COVID-19. These preliminary findings warrant further large-scale investigation.
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spelling pubmed-101608482023-05-05 Long Covid as an Indication for Heart Transplantation and Its Characteristics Rossi Neto, Joao Manoel Rossi, Raphael Machado Wolf, Plinio Jose Whitaker De Mello, Victor Bemfica Dantas, Daniel Chagas Santos, Carolina Casadei Dos Finger, Marco Aurelio Transplant Proc Article BACKGROUND: The post–acute cardiovascular manifestations of COVID-19, known as long COVID, have yet to be comprehensively characterized. There is also an increased risk of heart failure in individuals without cardiovascular disease before SARS-CoV-2 infection. The literature lacks information regarding the characteristics of patients with long COVID who developed advanced heart failure refractory to guideline-directed medical therapy. METHODS: We describe the characteristics of patients with long COVID (LC) who were listed for heart transplantation. The study population comprised 45 patients listed for heart transplantation, divided into 2 groups: patients with etiologies other than LC (n = 41) and patients with LC (n = 4) between January 2020 and March 2022. The endpoint of this study was the description of the characteristics of each group. RESULTS: The average duration of hospitalization after the acute infectious episode with SARS-CoV-2 was 150 ± 113 days, and all patients were hospitalized in New York Heart Association class IV. All LC patients were oligosymptomatic in the initial infection, did not require hospitalization in the acute phase, had a lower ejection fraction, used more intra-aortic balloon pumps, had lower pulmonary vascular resistance, and fewer comorbidities compared with other etiologies, suggesting a clinical feature compatible with low cardiac output rather than congestion. CONCLUSIONS: This study is an early investigation of patients listed for heart transplantation due to a complex syndrome of COVID-19. These preliminary findings warrant further large-scale investigation. Elsevier Inc. 2023-05-05 /pmc/articles/PMC10160848/ /pubmed/37150660 http://dx.doi.org/10.1016/j.transproceed.2023.03.071 Text en © 2023 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Rossi Neto, Joao Manoel
Rossi, Raphael Machado
Wolf, Plinio Jose Whitaker
De Mello, Victor Bemfica
Dantas, Daniel Chagas
Santos, Carolina Casadei Dos
Finger, Marco Aurelio
Long Covid as an Indication for Heart Transplantation and Its Characteristics
title Long Covid as an Indication for Heart Transplantation and Its Characteristics
title_full Long Covid as an Indication for Heart Transplantation and Its Characteristics
title_fullStr Long Covid as an Indication for Heart Transplantation and Its Characteristics
title_full_unstemmed Long Covid as an Indication for Heart Transplantation and Its Characteristics
title_short Long Covid as an Indication for Heart Transplantation and Its Characteristics
title_sort long covid as an indication for heart transplantation and its characteristics
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10160848/
https://www.ncbi.nlm.nih.gov/pubmed/37150660
http://dx.doi.org/10.1016/j.transproceed.2023.03.071
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