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Treponemal Antibody Seroprevalence Using a Multiplex Bead Assay from Samples Collected during the 2018 Nigeria HIV/AIDS Indicator and Impact Survey: Searching for Yaws in Nigeria
Yaws is a chronic, relapsing disease of skin, bone, and cartilage caused by Treponema pallidum subsp. pertenue. Yaws was last reported in Nigeria in 1996, although neighboring countries have recently reported cases. We investigated serological evidence for yaws among children aged 0–14 years in Nige...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society of Tropical Medicine and Hygiene
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10160906/ https://www.ncbi.nlm.nih.gov/pubmed/37037444 http://dx.doi.org/10.4269/ajtmh.22-0670 |
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author | Guagliardo, Sarah Anne J. Parameswaran, Nishanth Agala, Ndidi Abubakar, Ado Cooley, Gretchen Ye, Tun Kamb, Mary Mba, Nwando William, Nwachukwu Greby, Stacie Iriemenam, Nnaemeka Alagi, Matthias Okoye, McPaul Martin, Diana |
author_facet | Guagliardo, Sarah Anne J. Parameswaran, Nishanth Agala, Ndidi Abubakar, Ado Cooley, Gretchen Ye, Tun Kamb, Mary Mba, Nwando William, Nwachukwu Greby, Stacie Iriemenam, Nnaemeka Alagi, Matthias Okoye, McPaul Martin, Diana |
author_sort | Guagliardo, Sarah Anne J. |
collection | PubMed |
description | Yaws is a chronic, relapsing disease of skin, bone, and cartilage caused by Treponema pallidum subsp. pertenue. Yaws was last reported in Nigeria in 1996, although neighboring countries have recently reported cases. We investigated serological evidence for yaws among children aged 0–14 years in Nigeria by measuring antibodies to the treponemal antigens rp17 and TmpA in blood specimens from a 2018 nationally representative HIV survey using a multiplex bead assay. The presence of antibodies to both antigens (“double positive”) likely reflects current or recent treponemal infection. Overall, 1.9% (610/31,549) of children had anti-TmpA antibodies, 1.5% (476/31,549) had anti-rp17 antibodies, and 0.1% (39/31,549) were double positive. Among households, 0.5% (84/18,021) had a double-positive child, with a clustering of double-positive children. Although numbers are low, identification of antibodies to both TmpA and rp17 may warrant investigation, including more granular epidemiologic and clinical data, to assess the potential for continuing yaws transmission in Nigerian children. |
format | Online Article Text |
id | pubmed-10160906 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | The American Society of Tropical Medicine and Hygiene |
record_format | MEDLINE/PubMed |
spelling | pubmed-101609062023-05-06 Treponemal Antibody Seroprevalence Using a Multiplex Bead Assay from Samples Collected during the 2018 Nigeria HIV/AIDS Indicator and Impact Survey: Searching for Yaws in Nigeria Guagliardo, Sarah Anne J. Parameswaran, Nishanth Agala, Ndidi Abubakar, Ado Cooley, Gretchen Ye, Tun Kamb, Mary Mba, Nwando William, Nwachukwu Greby, Stacie Iriemenam, Nnaemeka Alagi, Matthias Okoye, McPaul Martin, Diana Am J Trop Med Hyg Short Report Yaws is a chronic, relapsing disease of skin, bone, and cartilage caused by Treponema pallidum subsp. pertenue. Yaws was last reported in Nigeria in 1996, although neighboring countries have recently reported cases. We investigated serological evidence for yaws among children aged 0–14 years in Nigeria by measuring antibodies to the treponemal antigens rp17 and TmpA in blood specimens from a 2018 nationally representative HIV survey using a multiplex bead assay. The presence of antibodies to both antigens (“double positive”) likely reflects current or recent treponemal infection. Overall, 1.9% (610/31,549) of children had anti-TmpA antibodies, 1.5% (476/31,549) had anti-rp17 antibodies, and 0.1% (39/31,549) were double positive. Among households, 0.5% (84/18,021) had a double-positive child, with a clustering of double-positive children. Although numbers are low, identification of antibodies to both TmpA and rp17 may warrant investigation, including more granular epidemiologic and clinical data, to assess the potential for continuing yaws transmission in Nigerian children. The American Society of Tropical Medicine and Hygiene 2023-04-10 2023-05 /pmc/articles/PMC10160906/ /pubmed/37037444 http://dx.doi.org/10.4269/ajtmh.22-0670 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Short Report Guagliardo, Sarah Anne J. Parameswaran, Nishanth Agala, Ndidi Abubakar, Ado Cooley, Gretchen Ye, Tun Kamb, Mary Mba, Nwando William, Nwachukwu Greby, Stacie Iriemenam, Nnaemeka Alagi, Matthias Okoye, McPaul Martin, Diana Treponemal Antibody Seroprevalence Using a Multiplex Bead Assay from Samples Collected during the 2018 Nigeria HIV/AIDS Indicator and Impact Survey: Searching for Yaws in Nigeria |
title | Treponemal Antibody Seroprevalence Using a Multiplex Bead Assay from Samples Collected during the 2018 Nigeria HIV/AIDS Indicator and Impact Survey: Searching for Yaws in Nigeria |
title_full | Treponemal Antibody Seroprevalence Using a Multiplex Bead Assay from Samples Collected during the 2018 Nigeria HIV/AIDS Indicator and Impact Survey: Searching for Yaws in Nigeria |
title_fullStr | Treponemal Antibody Seroprevalence Using a Multiplex Bead Assay from Samples Collected during the 2018 Nigeria HIV/AIDS Indicator and Impact Survey: Searching for Yaws in Nigeria |
title_full_unstemmed | Treponemal Antibody Seroprevalence Using a Multiplex Bead Assay from Samples Collected during the 2018 Nigeria HIV/AIDS Indicator and Impact Survey: Searching for Yaws in Nigeria |
title_short | Treponemal Antibody Seroprevalence Using a Multiplex Bead Assay from Samples Collected during the 2018 Nigeria HIV/AIDS Indicator and Impact Survey: Searching for Yaws in Nigeria |
title_sort | treponemal antibody seroprevalence using a multiplex bead assay from samples collected during the 2018 nigeria hiv/aids indicator and impact survey: searching for yaws in nigeria |
topic | Short Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10160906/ https://www.ncbi.nlm.nih.gov/pubmed/37037444 http://dx.doi.org/10.4269/ajtmh.22-0670 |
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