Identification of small-molecule protein–protein interaction inhibitors for NKG2D

NKG2D (natural-killer group 2, member D) is a homodimeric transmembrane receptor that plays an important role in NK, γδ(+), and CD8(+) T cell-mediated immune responses to environmental stressors such as viral or bacterial infections and oxidative stress. However, aberrant NKG2D signaling has also be...

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Detalles Bibliográficos
Autores principales: Thompson, Aaron A., Harbut, Michael B., Kung, Pei-Pei, Karpowich, Nathan K., Branson, Jeffrey D., Grant, Joanna C., Hagan, Deborah, Pascual, Heather A., Bai, Guoyun, Zavareh, Reza Beheshti, Coate, Heather R., Collins, Bernard C., Côte, Marjorie, Gelin, Christine F., Damm-Ganamet, Kelly L., Gholami, Hadi, Huff, Adam R., Limon, Luis, Lumb, Kevin J., Mak, Puiying A., Nakafuku, Kohki M., Price, Edmund V., Shih, Amy Y., Tootoonchi, Mandana, Vellore, Nadeem A., Wang, Jocelyn, Wei, Na, Ziff, Jeannie, Berger, Scott B., Edwards, James P., Gardet, Agnès, Sun, Siquan, Towne, Jennifer E., Venable, Jennifer D., Shi, Zhicai, Venkatesan, Hariharan, Rives, Marie-Laure, Sharma, Sujata, Shireman, Brock T., Allen, Samantha J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10160951/
https://www.ncbi.nlm.nih.gov/pubmed/37098070
http://dx.doi.org/10.1073/pnas.2216342120

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