Hypoxia induces downregulation of the tumor-suppressive sST2 in colorectal cancer cells via the HIF–nuclear IL-33–GATA3 pathway

As a decoy receptor, soluble ST2 (sST2) interferes with the function of the inflammatory cytokine interleukin (IL)-33. Decreased sST2 expression in colorectal cancer (CRC) cells promotes tumor growth via IL-33-mediated bioprocesses in the tumor microenvironment. In this study, we discovered that hyp...

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Detalles Bibliográficos
Autores principales: Akimoto, Miho, Susa, Takao, Okudaira, Noriyuki, Koshikawa, Nobuko, Hisaki, Harumi, Iizuka, Masayoshi, Okinaga, Hiroko, Takenaga, Keizo, Okazaki, Tomoki, Tamamori-Adachi, Mimi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10160999/
https://www.ncbi.nlm.nih.gov/pubmed/37094129
http://dx.doi.org/10.1073/pnas.2218033120

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