Malic Enzyme 1 as a Novel Anti‐Ferroptotic Regulator in Hepatic Ischemia/Reperfusion Injury (Adv. Sci. 13/2023)

Malic Enzyme 1 In article number 2205436, Xuexian Fang, Fudi Wang, and co‐workers discover Malic Enzyme 1 (ME1) as a novel ferroptosis inhibitory gene, which protects the liver function against ischemia/reperfusion (I/R) injury. The design is inspired by General Yue Fei (represents ME1), a national...

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Detalles Bibliográficos
Autores principales: Fang, Xuexian, Zhang, Jiawei, Li, You, Song, Yijing, Yu, Yingying, Cai, Zhaoxian, Lian, Fuzhi, Yang, Jun, Min, Junxia, Wang, Fudi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Frontispiece
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10161017/
http://dx.doi.org/10.1002/advs.202370079
Descripción
Sumario:Malic Enzyme 1 In article number 2205436, Xuexian Fang, Fudi Wang, and co‐workers discover Malic Enzyme 1 (ME1) as a novel ferroptosis inhibitory gene, which protects the liver function against ischemia/reperfusion (I/R) injury. The design is inspired by General Yue Fei (represents ME1), a national hero in the Song Dynasty (960‐1279) who accomplished great feats in many battles (represents ferroptosis‐induced liver injury during the process of I/R). This work provides a novel target and mechanistic insight into ferroptosis induced liver injury. [Image: see text]

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