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The temporal structure of REM sleep shows minute-scale fluctuations across brain and body in mice and humans

Rapid eye movement sleep (REM) is believed to have a binary temporal structure with “phasic” and “tonic" microstates, characterized by motoric activity versus quiescence, respectively. However, we observed in mice that the frequency of theta activity (a marker of rodent REM) fluctuates in a non...

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Autores principales: Bueno-Junior, Lezio S., Ruckstuhl, Maxwell S., Lim, Miranda M., Watson, Brendon O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10161068/
https://www.ncbi.nlm.nih.gov/pubmed/37094161
http://dx.doi.org/10.1073/pnas.2213438120
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author Bueno-Junior, Lezio S.
Ruckstuhl, Maxwell S.
Lim, Miranda M.
Watson, Brendon O.
author_facet Bueno-Junior, Lezio S.
Ruckstuhl, Maxwell S.
Lim, Miranda M.
Watson, Brendon O.
author_sort Bueno-Junior, Lezio S.
collection PubMed
description Rapid eye movement sleep (REM) is believed to have a binary temporal structure with “phasic” and “tonic" microstates, characterized by motoric activity versus quiescence, respectively. However, we observed in mice that the frequency of theta activity (a marker of rodent REM) fluctuates in a nonbinary fashion, with the extremes of that fluctuation correlating with phasic-type and tonic-type facial motricity. Thus, phasic and tonic REM may instead represent ends of a continuum. These cycles of brain physiology and facial movement occurred at 0.01 to 0.06 Hz, or infraslow frequencies, and affected cross-frequency coupling and neuronal activity in the neocortex, suggesting network functional impact. We then analyzed human data and observed that humans also demonstrate nonbinary phasic/tonic microstates, with continuous 0.01 to 0.04-Hz respiratory rate cycles matching the incidence of eye movements. These fundamental properties of REM can yield insights into our understanding of sleep health.
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spelling pubmed-101610682023-05-06 The temporal structure of REM sleep shows minute-scale fluctuations across brain and body in mice and humans Bueno-Junior, Lezio S. Ruckstuhl, Maxwell S. Lim, Miranda M. Watson, Brendon O. Proc Natl Acad Sci U S A Biological Sciences Rapid eye movement sleep (REM) is believed to have a binary temporal structure with “phasic” and “tonic" microstates, characterized by motoric activity versus quiescence, respectively. However, we observed in mice that the frequency of theta activity (a marker of rodent REM) fluctuates in a nonbinary fashion, with the extremes of that fluctuation correlating with phasic-type and tonic-type facial motricity. Thus, phasic and tonic REM may instead represent ends of a continuum. These cycles of brain physiology and facial movement occurred at 0.01 to 0.06 Hz, or infraslow frequencies, and affected cross-frequency coupling and neuronal activity in the neocortex, suggesting network functional impact. We then analyzed human data and observed that humans also demonstrate nonbinary phasic/tonic microstates, with continuous 0.01 to 0.04-Hz respiratory rate cycles matching the incidence of eye movements. These fundamental properties of REM can yield insights into our understanding of sleep health. National Academy of Sciences 2023-04-24 2023-05-02 /pmc/articles/PMC10161068/ /pubmed/37094161 http://dx.doi.org/10.1073/pnas.2213438120 Text en Copyright © 2023 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by-nc-nd/4.0/This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Biological Sciences
Bueno-Junior, Lezio S.
Ruckstuhl, Maxwell S.
Lim, Miranda M.
Watson, Brendon O.
The temporal structure of REM sleep shows minute-scale fluctuations across brain and body in mice and humans
title The temporal structure of REM sleep shows minute-scale fluctuations across brain and body in mice and humans
title_full The temporal structure of REM sleep shows minute-scale fluctuations across brain and body in mice and humans
title_fullStr The temporal structure of REM sleep shows minute-scale fluctuations across brain and body in mice and humans
title_full_unstemmed The temporal structure of REM sleep shows minute-scale fluctuations across brain and body in mice and humans
title_short The temporal structure of REM sleep shows minute-scale fluctuations across brain and body in mice and humans
title_sort temporal structure of rem sleep shows minute-scale fluctuations across brain and body in mice and humans
topic Biological Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10161068/
https://www.ncbi.nlm.nih.gov/pubmed/37094161
http://dx.doi.org/10.1073/pnas.2213438120
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