Nano‐LYTACs for Degradation of Membrane Proteins and Inhibition of CD24/Siglec‐10 Signaling Pathway

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Lysosome‐targeting chimeras (LYTACs) are an emerging therapeutic modality that effectively degrade cancer cell membranes and extracellular target proteins. In this study, a nanosphere‐based LYTAC degradation system is developed. The amphiphilic peptide‐modified N‐acetylgalactosamine (GalNAc) can sel...

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Detalles Bibliográficos
Autores principales: Wang, Kun, Yu, Albert, Liu, Kewei, Feng, Chunyan, Hou, Yibo, Chen, Jiawei, Ma, Shaohua, Huang, Laiqiang, Dai, Xiaoyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10161071/
https://www.ncbi.nlm.nih.gov/pubmed/36866919
http://dx.doi.org/10.1002/advs.202300288
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