Early Endosomes Act as Local Exocytosis Hubs to Repair Endothelial Membrane Damage (Adv. Sci. 13/2023)

Plasma Membrane Resealing Endothelial cells (yellow) comprise the inner lining of blood vessels. Following laser‐induced injury of their plasma membrane, the membrane wound must be repaired to prevent cell death. This is achieved by early endosomes (red circles), compartments involved in conventiona...

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Detalles Bibliográficos
Autores principales: Raj, Nikita, Greune, Lilo, Kahms, Martin, Mildner, Karina, Franzkoch, Rico, Psathaki, Olympia Ekaterini, Zobel, Thomas, Zeuschner, Dagmar, Klingauf, Jürgen, Gerke, Volker
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10161106/
http://dx.doi.org/10.1002/advs.202370078
Descripción
Sumario:Plasma Membrane Resealing Endothelial cells (yellow) comprise the inner lining of blood vessels. Following laser‐induced injury of their plasma membrane, the membrane wound must be repaired to prevent cell death. This is achieved by early endosomes (red circles), compartments involved in conventional endocytic transport, which are repurposed for wound repair. They undergo Ca(2+)‐dependent exocytosis to provide membrane for resealing of the wound. More details can be found in article number 2300244 by Volker Gerke and co‐workers. [Image: see text]

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