Carbon dioxide/bicarbonate is required for sensitive inactivation of mammalian glyceraldehyde-3-phosphate dehydrogenase by hydrogen peroxide

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) contains an active site Cys and is one of the most sensitive cellular enzymes to oxidative inactivation and redox regulation. Here, we show that inactivation by hydrogen peroxide is strongly enhanced in the presence of carbon dioxide/bicarbonate. Inac...

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Detalles Bibliográficos
Autores principales: Winterbourn, Christine C., Peskin, Alexander V., Kleffmann, Torsten, Radi, Rafael, Pace, Paul E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10161126/
https://www.ncbi.nlm.nih.gov/pubmed/37098065
http://dx.doi.org/10.1073/pnas.2221047120

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