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Risk of adverse pregnancy and infant outcomes associated with prenatal Zika virus infection: a post-epidemic cohort in Central-West Brazil

This study aimed to estimate the risks of adverse infant outcomes in the first year of life related to prenatal Zika virus (ZIKV) exposure. A prospective cohort of pregnant women with rash was recruited in Central-West Brazil in a post-epidemic period (January 2017 to April 2019). We evaluated parti...

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Autores principales: Rosado, Luiza Emylce Pela, Martelli, Celina M. Turchi, Brickley, Elizabeth B., Gomes, Maria Barbara Franco, de Toledo Lima, Talita, da Costa, Paulo Sergio Sucasas, de Ávila, Marcos Pereira, Viggiano, Marcello Braga, do Amaral, Waldemar Naves, de Rezende Feres, Valeria Christina, Fiaccadori, Fabiola Souza, de Sene Amancio Zara, Ana Laura, Ferreira-Lopes, Angela, Turchi, Marilia Dalva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10161159/
https://www.ncbi.nlm.nih.gov/pubmed/37147405
http://dx.doi.org/10.1038/s41598-023-33334-5
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author Rosado, Luiza Emylce Pela
Martelli, Celina M. Turchi
Brickley, Elizabeth B.
Gomes, Maria Barbara Franco
de Toledo Lima, Talita
da Costa, Paulo Sergio Sucasas
de Ávila, Marcos Pereira
Viggiano, Marcello Braga
do Amaral, Waldemar Naves
de Rezende Feres, Valeria Christina
Fiaccadori, Fabiola Souza
de Sene Amancio Zara, Ana Laura
Ferreira-Lopes, Angela
Turchi, Marilia Dalva
author_facet Rosado, Luiza Emylce Pela
Martelli, Celina M. Turchi
Brickley, Elizabeth B.
Gomes, Maria Barbara Franco
de Toledo Lima, Talita
da Costa, Paulo Sergio Sucasas
de Ávila, Marcos Pereira
Viggiano, Marcello Braga
do Amaral, Waldemar Naves
de Rezende Feres, Valeria Christina
Fiaccadori, Fabiola Souza
de Sene Amancio Zara, Ana Laura
Ferreira-Lopes, Angela
Turchi, Marilia Dalva
author_sort Rosado, Luiza Emylce Pela
collection PubMed
description This study aimed to estimate the risks of adverse infant outcomes in the first year of life related to prenatal Zika virus (ZIKV) exposure. A prospective cohort of pregnant women with rash was recruited in Central-West Brazil in a post-epidemic period (January 2017 to April 2019). We evaluated participants’ medical histories and performed ZIKV diagnostic testing using molecular (reverse transcription polymerase chain reaction [RT-PCR]) and serologic (immunoglobulin [Ig]M and plaque reduction neutralization tests [PRNT(90)]) assays. The ZIKV-positive group included both RT-PCR-confirmed cases as well as IgM and/or PRNT(90)-positive probable cases. Children were evaluated at birth and in the first 12 months of life. Transfontanellar ultrasound, central nervous system computed tomography, eye fundoscopy and retinography were performed. We estimated the absolute risk and 95% confidence interval (95% CI) of adverse infant outcomes among confirmed prenatally ZIKV-exposed children. Among 81 pregnant women with rash, 43 (53.1%) were ZIKV infected. The absolute risk of microcephaly among offspring of ZIKV-infected pregnant women was 7.0% (95% CI: 1.5–19.1), including the two cases of microcephaly detected prenatally and one detected postnatally. In total, 54.5% (95% CI: 39.8–68.7) of children in the ZIKV-exposed group had at least one ophthalmic abnormality, with the most frequent abnormalities being focal pigmentary mottling and chorioretinal atrophy or scarring. Our findings reinforce the importance of long-term monitoring of prenatally ZIKV-exposed children born apparently asymptomatic for Congenital Zika Syndrome.
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spelling pubmed-101611592023-05-07 Risk of adverse pregnancy and infant outcomes associated with prenatal Zika virus infection: a post-epidemic cohort in Central-West Brazil Rosado, Luiza Emylce Pela Martelli, Celina M. Turchi Brickley, Elizabeth B. Gomes, Maria Barbara Franco de Toledo Lima, Talita da Costa, Paulo Sergio Sucasas de Ávila, Marcos Pereira Viggiano, Marcello Braga do Amaral, Waldemar Naves de Rezende Feres, Valeria Christina Fiaccadori, Fabiola Souza de Sene Amancio Zara, Ana Laura Ferreira-Lopes, Angela Turchi, Marilia Dalva Sci Rep Article This study aimed to estimate the risks of adverse infant outcomes in the first year of life related to prenatal Zika virus (ZIKV) exposure. A prospective cohort of pregnant women with rash was recruited in Central-West Brazil in a post-epidemic period (January 2017 to April 2019). We evaluated participants’ medical histories and performed ZIKV diagnostic testing using molecular (reverse transcription polymerase chain reaction [RT-PCR]) and serologic (immunoglobulin [Ig]M and plaque reduction neutralization tests [PRNT(90)]) assays. The ZIKV-positive group included both RT-PCR-confirmed cases as well as IgM and/or PRNT(90)-positive probable cases. Children were evaluated at birth and in the first 12 months of life. Transfontanellar ultrasound, central nervous system computed tomography, eye fundoscopy and retinography were performed. We estimated the absolute risk and 95% confidence interval (95% CI) of adverse infant outcomes among confirmed prenatally ZIKV-exposed children. Among 81 pregnant women with rash, 43 (53.1%) were ZIKV infected. The absolute risk of microcephaly among offspring of ZIKV-infected pregnant women was 7.0% (95% CI: 1.5–19.1), including the two cases of microcephaly detected prenatally and one detected postnatally. In total, 54.5% (95% CI: 39.8–68.7) of children in the ZIKV-exposed group had at least one ophthalmic abnormality, with the most frequent abnormalities being focal pigmentary mottling and chorioretinal atrophy or scarring. Our findings reinforce the importance of long-term monitoring of prenatally ZIKV-exposed children born apparently asymptomatic for Congenital Zika Syndrome. Nature Publishing Group UK 2023-05-05 /pmc/articles/PMC10161159/ /pubmed/37147405 http://dx.doi.org/10.1038/s41598-023-33334-5 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Rosado, Luiza Emylce Pela
Martelli, Celina M. Turchi
Brickley, Elizabeth B.
Gomes, Maria Barbara Franco
de Toledo Lima, Talita
da Costa, Paulo Sergio Sucasas
de Ávila, Marcos Pereira
Viggiano, Marcello Braga
do Amaral, Waldemar Naves
de Rezende Feres, Valeria Christina
Fiaccadori, Fabiola Souza
de Sene Amancio Zara, Ana Laura
Ferreira-Lopes, Angela
Turchi, Marilia Dalva
Risk of adverse pregnancy and infant outcomes associated with prenatal Zika virus infection: a post-epidemic cohort in Central-West Brazil
title Risk of adverse pregnancy and infant outcomes associated with prenatal Zika virus infection: a post-epidemic cohort in Central-West Brazil
title_full Risk of adverse pregnancy and infant outcomes associated with prenatal Zika virus infection: a post-epidemic cohort in Central-West Brazil
title_fullStr Risk of adverse pregnancy and infant outcomes associated with prenatal Zika virus infection: a post-epidemic cohort in Central-West Brazil
title_full_unstemmed Risk of adverse pregnancy and infant outcomes associated with prenatal Zika virus infection: a post-epidemic cohort in Central-West Brazil
title_short Risk of adverse pregnancy and infant outcomes associated with prenatal Zika virus infection: a post-epidemic cohort in Central-West Brazil
title_sort risk of adverse pregnancy and infant outcomes associated with prenatal zika virus infection: a post-epidemic cohort in central-west brazil
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10161159/
https://www.ncbi.nlm.nih.gov/pubmed/37147405
http://dx.doi.org/10.1038/s41598-023-33334-5
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