CAG-Repeat RNA Hairpin Folding and Recruitment to Nuclear Speckles with a Pivotal Role of ATP as a Cosolute

[Image: see text] A hallmark of Huntington’s disease (HD) is a prolonged polyglutamine sequence in the huntingtin protein and, correspondingly, an expanded cytosine, adenine, and guanine (CAG) triplet repeat region in the mRNA. A majority of studies investigating disease pathology were concerned wit...

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Detalles Bibliográficos
Autores principales: Hautke, Alexander, Voronin, Arthur, Idiris, Fathia, Riel, Anton, Lindner, Felix, Lelièvre-Büttner, Amandine, Zhu, Jikang, Appel, Bettina, Fatti, Edoardo, Weis, Karsten, Müller, Sabine, Schug, Alexander, Ebbinghaus, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10161218/
https://www.ncbi.nlm.nih.gov/pubmed/37062072
http://dx.doi.org/10.1021/jacs.2c13653

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