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On-Tissue Chemical Derivatization for Comprehensive Mapping of Brain Carboxyl and Aldehyde Metabolites by MALDI–MS Imaging

[Image: see text] The visualization of small metabolites by MALDI mass spectrometry imaging in brain tissue sections is challenging due to low detection sensitivity and high background interference. We present an on-tissue chemical derivatization MALDI mass spectrometry imaging approach for the comp...

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Detalles Bibliográficos
Autores principales:	Kaya, Ibrahim, Schembri, Luke S., Nilsson, Anna, Shariatgorji, Reza, Baijnath, Sooraj, Zhang, Xiaoqun, Bezard, Erwan, Svenningsson, Per, Odell, Luke R., Andrén, Per E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10161219/ https://www.ncbi.nlm.nih.gov/pubmed/37052344 http://dx.doi.org/10.1021/jasms.2c00336

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