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Malignant adipocytic tumours: A 20‑year single‑centre retrospective study
Adipocytic tumours are the most common soft tissue neoplasms. Among them, liposarcoma is the most frequent malignant neoplasm. However, to the best of our knowledge, no previously published study has assessed the evolution and oncological prognosis of the different subtypes of liposarcoma at the ret...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10161324/ https://www.ncbi.nlm.nih.gov/pubmed/37153046 http://dx.doi.org/10.3892/ol.2023.13833 |
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author | Mendoza-Moreno, Fernando Matías-García, Belén Quiroga-Valcárcel, Ana García-Moreno Nisa, Francisca Díez-Corral, Cristina Blázquez-Martín, Alma Vera-Mansilla, Cristina Ovejero-Merino, Enrique Díez-Alonso, Manuel Diego-García, Lucía Alvarez-Mon, Melchor Ortega, Miguel A. Gutiérrez-Calvo, Alberto |
author_facet | Mendoza-Moreno, Fernando Matías-García, Belén Quiroga-Valcárcel, Ana García-Moreno Nisa, Francisca Díez-Corral, Cristina Blázquez-Martín, Alma Vera-Mansilla, Cristina Ovejero-Merino, Enrique Díez-Alonso, Manuel Diego-García, Lucía Alvarez-Mon, Melchor Ortega, Miguel A. Gutiérrez-Calvo, Alberto |
author_sort | Mendoza-Moreno, Fernando |
collection | PubMed |
description | Adipocytic tumours are the most common soft tissue neoplasms. Among them, liposarcoma is the most frequent malignant neoplasm. However, to the best of our knowledge, no previously published study has assessed the evolution and oncological prognosis of the different subtypes of liposarcoma at the retroperitoneal level compared with at other locations. The present study is a retrospective observational study in which all patients were operated on between October 2000 and January 2020 with a histological diagnosis of liposarcoma. Variables, such as age, sex, location, histological type, recurrence, type of treatment and mortality, among others, were analysed. The patients were divided into two groups: Group A (retroperitoneal location) and group B (non-retroperitoneal location). A total of 52 patients with a diagnosis of liposarcoma (17 women and 35 men) and a mean age of 57.2±15.9 years were assessed. A total of 16 patients were classified into group A and 36 into group B. The OR of recurrence was 1.5 (P=0.02) for R1 vs. R0 resection in group A. The OR of recurrence in group B for R1 vs. R0 resection was 1.8 (P=0.77), whereas for R2 vs. R0 resection, the OR was 69 (P=0.011). In conclusion, 52 cases of malignant adipocytic tumours collected during 2000–2020 were analysed with the new World Health Organization classification (updated 2020). Although its recurrence potential and capacity for distant metastasis depended on each histological type, surgical treatment with unaffected margins was the main prognostic factor for survival. The present study identified differences in relation to the survival of each histological subtype and its location, finding greater survival in dedifferentiated liposarcoma, myxoid liposarcoma and pleomorphic liposarcoma located at the extraperitoneal level than in the retroperitoneal location. Resectability was not influenced by liposarcoma location. |
format | Online Article Text |
id | pubmed-10161324 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-101613242023-05-06 Malignant adipocytic tumours: A 20‑year single‑centre retrospective study Mendoza-Moreno, Fernando Matías-García, Belén Quiroga-Valcárcel, Ana García-Moreno Nisa, Francisca Díez-Corral, Cristina Blázquez-Martín, Alma Vera-Mansilla, Cristina Ovejero-Merino, Enrique Díez-Alonso, Manuel Diego-García, Lucía Alvarez-Mon, Melchor Ortega, Miguel A. Gutiérrez-Calvo, Alberto Oncol Lett Articles Adipocytic tumours are the most common soft tissue neoplasms. Among them, liposarcoma is the most frequent malignant neoplasm. However, to the best of our knowledge, no previously published study has assessed the evolution and oncological prognosis of the different subtypes of liposarcoma at the retroperitoneal level compared with at other locations. The present study is a retrospective observational study in which all patients were operated on between October 2000 and January 2020 with a histological diagnosis of liposarcoma. Variables, such as age, sex, location, histological type, recurrence, type of treatment and mortality, among others, were analysed. The patients were divided into two groups: Group A (retroperitoneal location) and group B (non-retroperitoneal location). A total of 52 patients with a diagnosis of liposarcoma (17 women and 35 men) and a mean age of 57.2±15.9 years were assessed. A total of 16 patients were classified into group A and 36 into group B. The OR of recurrence was 1.5 (P=0.02) for R1 vs. R0 resection in group A. The OR of recurrence in group B for R1 vs. R0 resection was 1.8 (P=0.77), whereas for R2 vs. R0 resection, the OR was 69 (P=0.011). In conclusion, 52 cases of malignant adipocytic tumours collected during 2000–2020 were analysed with the new World Health Organization classification (updated 2020). Although its recurrence potential and capacity for distant metastasis depended on each histological type, surgical treatment with unaffected margins was the main prognostic factor for survival. The present study identified differences in relation to the survival of each histological subtype and its location, finding greater survival in dedifferentiated liposarcoma, myxoid liposarcoma and pleomorphic liposarcoma located at the extraperitoneal level than in the retroperitoneal location. Resectability was not influenced by liposarcoma location. D.A. Spandidos 2023-04-21 /pmc/articles/PMC10161324/ /pubmed/37153046 http://dx.doi.org/10.3892/ol.2023.13833 Text en Copyright: © Mendoza-Moreno et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Mendoza-Moreno, Fernando Matías-García, Belén Quiroga-Valcárcel, Ana García-Moreno Nisa, Francisca Díez-Corral, Cristina Blázquez-Martín, Alma Vera-Mansilla, Cristina Ovejero-Merino, Enrique Díez-Alonso, Manuel Diego-García, Lucía Alvarez-Mon, Melchor Ortega, Miguel A. Gutiérrez-Calvo, Alberto Malignant adipocytic tumours: A 20‑year single‑centre retrospective study |
title | Malignant adipocytic tumours: A 20‑year single‑centre retrospective study |
title_full | Malignant adipocytic tumours: A 20‑year single‑centre retrospective study |
title_fullStr | Malignant adipocytic tumours: A 20‑year single‑centre retrospective study |
title_full_unstemmed | Malignant adipocytic tumours: A 20‑year single‑centre retrospective study |
title_short | Malignant adipocytic tumours: A 20‑year single‑centre retrospective study |
title_sort | malignant adipocytic tumours: a 20‑year single‑centre retrospective study |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10161324/ https://www.ncbi.nlm.nih.gov/pubmed/37153046 http://dx.doi.org/10.3892/ol.2023.13833 |
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