BACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides

BACKGROUND: Abnormal accumulation of amyloid beta peptide (Aβ) in the brain induces a cascade of pathological changes in Alzheimer’s disease (AD), and inhibiting BACE1, which is required for Aβ generation, is therefore being explored for the treatment of AD by reducing Aβ accumulation. As Bace1 knoc...

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Detalles Bibliográficos
Autores principales: Zhou, John, Singh, Neeraj, Galske, James, Hudobenko, Jacob, Hu, Xiangyou, Yan, Riqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10161466/
https://www.ncbi.nlm.nih.gov/pubmed/37143090
http://dx.doi.org/10.1186/s13024-023-00611-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10161466/
https://www.ncbi.nlm.nih.gov/pubmed/37143090
http://dx.doi.org/10.1186/s13024-023-00611-w

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