Cargando…

BACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides

BACKGROUND: Abnormal accumulation of amyloid beta peptide (Aβ) in the brain induces a cascade of pathological changes in Alzheimer’s disease (AD), and inhibiting BACE1, which is required for Aβ generation, is therefore being explored for the treatment of AD by reducing Aβ accumulation. As Bace1 knoc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, John, Singh, Neeraj, Galske, James, Hudobenko, Jacob, Hu, Xiangyou, Yan, Riqiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10161466/ https://www.ncbi.nlm.nih.gov/pubmed/37143090 http://dx.doi.org/10.1186/s13024-023-00611-w

Ejemplares similares

Targeted BACE-1 inhibition in microglia enhances amyloid clearance and improved cognitive performance
por: Singh, Neeraj, et al.
Publicado: (2022)

Bace1 Deletion in the Adult Reverses Epileptiform Activity and Sleep–wake Disturbances in AD Mice
por: Yao, Annie Y., et al.
Publicado: (2023)

BACE1 deletion in the adult mouse reverses preformed amyloid deposition and improves cognitive functions
por: Hu, Xiangyou, et al.
Publicado: (2018)

BACE1 controls synaptic function through modulating release of synaptic vesicles
por: Das, Brati, et al.
Publicado: (2021)

BACE-1 inhibition facilitates the transition from homeostatic microglia to DAM-1
por: Singh, Neeraj, et al.
Publicado: (2022)

Astrocyte-derived clusterin suppresses amyloid formation in vivo
por: Wojtas, Aleksandra M., et al.
Publicado: (2020)

BACE1 Deficiency Causes Abnormal Neuronal Clustering in the Dentate Gyrus
por: Hou, Hailong, et al.
Publicado: (2017)

Ginsenoside compound K promotes β-amyloid peptide clearance in primary astrocytes via autophagy enhancement
por: GUO, JINHUI, et al.
Publicado: (2014)

Exploration of C-terminal CX3CL1 for reducing age-dependent neurodegeneration
por: Hudobenko, Jacob, et al.
Publicado: (2023)

The intracellular domain of CX3CL1 regulates adult neurogenesis and Alzheimer’s amyloid pathology
por: Fan, Qingyuan, et al.
Publicado: (2019)

The effect of BACE1-AS on β-amyloid generation by regulating BACE1 mRNA expression
por: Li, Fan, et al.
Publicado: (2019)

Role of BACE1 in Alzheimer’s synaptic function
por: Das, Brati, et al.
Publicado: (2017)

Aβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer’s disease progression
por: Liebsch, Filip, et al.
Publicado: (2019)

Stepping closer to treating Alzheimer’s disease patients with BACE1 inhibitor drugs
por: Yan, Riqiang
Publicado: (2016)

Clusterin Is Required for β-Amyloid Toxicity in Human iPSC-Derived Neurons
por: Robbins, Jacqueline P., et al.
Publicado: (2018)

Ubiquitin binds the amyloid β peptide and interferes with its clearance pathways
por: Bellia, F., et al.
Publicado: (2019)

Relation of plasma β‐amyloid, clusterin, and tau with cerebral microbleeds: Framingham Heart Study
por: Romero, José Rafael, et al.
Publicado: (2020)

Apolipoprotein E and clusterin inhibit the early phase of amyloid-β aggregation in an in vitro model of cerebral amyloid angiopathy
por: Endo, Yoshinori, et al.
Publicado: (2019)

The CX3CL1 intracellular domain exhibits neuroprotection via insulin receptor/insulin-like growth factor receptor signaling
por: Gayen, Manoshi, et al.
Publicado: (2022)

The role of APP and BACE1 trafficking in APP processing and amyloid-β generation
por: Zhang, Xiaojie, et al.
Publicado: (2013)

Mechanisms of amyloid-β34 generation indicate a pivotal role for BACE1 in amyloid homeostasis
por: Ulku, Irem, et al.
Publicado: (2023)

Distinct anterograde trafficking pathways of BACE1 and amyloid precursor protein from the TGN and the regulation of amyloid-β production
por: Tan, Jing Zhi A., et al.
Publicado: (2020)

Heparan sulfate regulates amyloid precursor protein processing by BACE1, the Alzheimer's β-secretase
por: Scholefield, Zoe, et al.
Publicado: (2003)

Mechanisms of Amyloid-β Peptide Clearance: Potential Therapeutic Targets for Alzheimer’s Disease
por: Yoon, Sang-Sun, et al.
Publicado: (2012)

Amyloid-β and Astrocytes Interplay in Amyloid-β Related Disorders
por: Batarseh, Yazan S., et al.
Publicado: (2016)

Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt–PCP–JNK pathway
por: Killick, R, et al.
Publicado: (2014)

Rippled β-Sheet Formation by an Amyloid-β Fragment Indicates Expanded Scope of Sequence Space for Enantiomeric β-Sheet Peptide Coassembly
por: Urban, Jennifer M., et al.
Publicado: (2019)

Extracellular clusterin limits the uptake of α‐synuclein fibrils by murine and human astrocytes
por: Filippini, Alice, et al.
Publicado: (2020)

The anti-inflammatory Annexin A1 induces the clearance and degradation of the amyloid-β peptide
por: Ries, Miriam, et al.
Publicado: (2016)

Dynamin 1 Regulates Amyloid Generation through Modulation of BACE-1
por: Zhu, Li, et al.
Publicado: (2012)

Activation of PKR Causes Amyloid ß-Peptide Accumulation via De-Repression of BACE1 Expression
por: ILL-Raga, Gerard, et al.
Publicado: (2011)

BACE1 inhibition more effectively suppresses initiation than progression of β-amyloid pathology
por: Peters, Finn, et al.
Publicado: (2018)

Clusterin facilitates apoptotic cell clearance and prevents apoptotic cell-induced autoimmune responses
por: Cunin, P, et al.
Publicado: (2016)

β-site amyloid precursor protein-cleaving enzyme 1(BACE1) inhibitor treatment induces Aβ5-X peptides through alternative amyloid precursor protein cleavage
por: Portelius, Erik, et al.
Publicado: (2014)

Physiological Functions of the β-Site Amyloid Precursor Protein Cleaving Enzyme 1 and 2
por: Yan, Riqiang
Publicado: (2017)

Identification of BACE2 as an avid ß-amyloid-degrading protease
por: Abdul-Hay, Samer O, et al.
Publicado: (2012)

Amyloid Beta-Peptide Increases BACE1 Translation through the Phosphorylation of the Eukaryotic Initiation Factor-2α
por: Picón-Pagès, Pol, et al.
Publicado: (2020)

Icariside II inhibits lipopolysaccharide-induced inflammation and amyloid production in rat astrocytes by regulating IKK/IκB/NF-κB/BACE1 signaling pathway
por: Zheng, Yong, et al.
Publicado: (2019)

Attenuated ability of BACE1 to cleave the amyloid precursor protein via silencing long noncoding RNA BACE1-AS expression
por: LIU, TE, et al.
Publicado: (2014)

Autophagy is involved in oligodendroglial precursor-mediated clearance of amyloid peptide
por: Li, Wenxia, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_qrb2nb9uvv5392pbu33fge1bqu