Microbial dysbiosis and the host airway epithelial response: insights into HIV-associated COPD using multi’omics profiling

BACKGROUND: People living with HIV (PLWH) are at increased risk of developing Chronic Obstructive Pulmonary Disease (COPD) independent of cigarette smoking. We hypothesized that dysbiosis in PLWH is associated with epigenetic and transcriptomic disruptions in the airway epithelium. METHODS: Airway e...

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Detalles Bibliográficos
Autores principales: Jude, Marcia Smiti, Yang, Chen Xi, Filho, Fernando Studart Leitao, Hernandez Cordero, Ana I., Yang, Julia, Shaipanich, Tawimas, Li, Xuan, Lin, David, MacIsaac, Julie, Kobor, Michael S., Sinha, Sunita, Nislow, Corey, Singh, Amrit, Lam, Wan, Lam, Stephen, Guillemi, Silvia, Harris, Marianne, Montaner, Julio, Ng, Raymond T., Carlsten, Christopher, Paul Man, S. F., Sin, Don D., Leung, Janice M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10161506/
https://www.ncbi.nlm.nih.gov/pubmed/37143066
http://dx.doi.org/10.1186/s12931-023-02431-4

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