The impact of epigenetic landscape on ovarian cells in infertile older women undergoing IVF procedures

The constant decline in fertility and older reproductive age is the major cause of low clinical pregnancy rates in industrialised countries. Epigenetic mechanisms impact on proper embryonic development in women undergoing in vitro fertilisation (IVF) protocols. Here, we describe the main epigenetic...

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Detalles Bibliográficos
Autores principales: Sgueglia, Giulia, Longobardi, Salvatore, Valerio, Domenico, Campitiello, Maria Rosaria, Colacurci, Nicola, Di Pietro, Cinzia, Battaglia, Rosalia, D’Hooghe, Thomas, Altucci, Lucia, Dell’Aversana, Carmela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10161563/
https://www.ncbi.nlm.nih.gov/pubmed/37143127
http://dx.doi.org/10.1186/s13148-023-01490-0
Descripción
Sumario:The constant decline in fertility and older reproductive age is the major cause of low clinical pregnancy rates in industrialised countries. Epigenetic mechanisms impact on proper embryonic development in women undergoing in vitro fertilisation (IVF) protocols. Here, we describe the main epigenetic modifications that may influence female reproduction and could affect IVF success. GRAPHICAL ABSTRACT: [Image: see text]

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