A Pronectin™ AXL-targeted first-in-class bispecific T cell engager (pAXLxCD3ε) for ovarian cancer

BACKGROUND: Pronectins™ are a new class of fibronectin-3-domain 14th-derived (14Fn3) antibody mimics that can be engineered as bispecific T cell engager (BTCE) to redirect immune effector cells against cancer. We describe here the in vitro and in vivo activity of a Pronectin™ AXL-targeted first-in-c...

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Detalles Bibliográficos
Autores principales: Riillo, Caterina, Polerà, Nicoletta, Di Martino, Maria Teresa, Juli, Giada, Hokanson, Craig A., Odineca, Tatjana, Signorelli, Stefania, Grillone, Katia, Ascrizzi, Serena, Mancuso, Antonia, Staropoli, Nicoletta, Caparello, Basilio, Cerra, Maria, Nisticò, Giuseppe, Tagliaferri, Pierosandro, Crea, Roberto, Caracciolo, Daniele, Tassone, Pierfrancesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10161629/
https://www.ncbi.nlm.nih.gov/pubmed/37143061
http://dx.doi.org/10.1186/s12967-023-04101-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10161629/
https://www.ncbi.nlm.nih.gov/pubmed/37143061
http://dx.doi.org/10.1186/s12967-023-04101-x

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