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Handgrip strength is associated with risks of new-onset stroke and heart disease: results from 3 prospective cohorts

BACKGROUND: Stroke and heart disease are two major contributors to the global disease burden. We aimed to evaluate and compare the roles of different handgrip strength (HGS) expressions in predicting stroke and heart disease in three nationally representative cohorts. METHODS: This longitudinal stud...

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Autores principales: Li, Guochen, Lu, Yanqiang, Shao, Liping, Wu, Luying, Qiao, Yanan, Ding, Yi, Ke, Chaofu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10161641/
https://www.ncbi.nlm.nih.gov/pubmed/37142986
http://dx.doi.org/10.1186/s12877-023-03953-8
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author Li, Guochen
Lu, Yanqiang
Shao, Liping
Wu, Luying
Qiao, Yanan
Ding, Yi
Ke, Chaofu
author_facet Li, Guochen
Lu, Yanqiang
Shao, Liping
Wu, Luying
Qiao, Yanan
Ding, Yi
Ke, Chaofu
author_sort Li, Guochen
collection PubMed
description BACKGROUND: Stroke and heart disease are two major contributors to the global disease burden. We aimed to evaluate and compare the roles of different handgrip strength (HGS) expressions in predicting stroke and heart disease in three nationally representative cohorts. METHODS: This longitudinal study used data from the Health and Retirement Study (HRS), the Survey of Health, Ageing, and Retirement in Europe (SHARE), and the China Health and Retirement Longitudinal Study (CHARLS). The Cox proportional hazard model was applied to analyze the relationship between HGS and stroke and heart disease, and Harrell’s C index was used to assess the predictive abilities of different HGS expressions. RESULTS: A total of 4,407 participants suffered from stroke and 9,509 from heart disease during follow-up. Compared with the highest quartile, participants in the lowest quartile of dominant HGS, absolute HGS and relative HGS possessed a significantly higher risk of new-onset stroke in Europe, America, and China (all P < 0.05). After adding HGS to office-based risk factors, there were minimal or no differences in the increases of Harrell’s C indexes among three HGS expressions. In contrast, the modest association between HGS and heart disease was only seen in SHARE and HRS, but not in CHARLS. CONCLUSION: Our findings support that HGS can be used as an independent predictor of stroke in middle-aged and older European, American and Chinese populations, and the predictive ability of HGS may not depend on how it is expressed. The relationship between HGS and heart disease calls for further validation. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12877-023-03953-8.
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spelling pubmed-101616412023-05-06 Handgrip strength is associated with risks of new-onset stroke and heart disease: results from 3 prospective cohorts Li, Guochen Lu, Yanqiang Shao, Liping Wu, Luying Qiao, Yanan Ding, Yi Ke, Chaofu BMC Geriatr Research BACKGROUND: Stroke and heart disease are two major contributors to the global disease burden. We aimed to evaluate and compare the roles of different handgrip strength (HGS) expressions in predicting stroke and heart disease in three nationally representative cohorts. METHODS: This longitudinal study used data from the Health and Retirement Study (HRS), the Survey of Health, Ageing, and Retirement in Europe (SHARE), and the China Health and Retirement Longitudinal Study (CHARLS). The Cox proportional hazard model was applied to analyze the relationship between HGS and stroke and heart disease, and Harrell’s C index was used to assess the predictive abilities of different HGS expressions. RESULTS: A total of 4,407 participants suffered from stroke and 9,509 from heart disease during follow-up. Compared with the highest quartile, participants in the lowest quartile of dominant HGS, absolute HGS and relative HGS possessed a significantly higher risk of new-onset stroke in Europe, America, and China (all P < 0.05). After adding HGS to office-based risk factors, there were minimal or no differences in the increases of Harrell’s C indexes among three HGS expressions. In contrast, the modest association between HGS and heart disease was only seen in SHARE and HRS, but not in CHARLS. CONCLUSION: Our findings support that HGS can be used as an independent predictor of stroke in middle-aged and older European, American and Chinese populations, and the predictive ability of HGS may not depend on how it is expressed. The relationship between HGS and heart disease calls for further validation. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12877-023-03953-8. BioMed Central 2023-05-04 /pmc/articles/PMC10161641/ /pubmed/37142986 http://dx.doi.org/10.1186/s12877-023-03953-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Li, Guochen
Lu, Yanqiang
Shao, Liping
Wu, Luying
Qiao, Yanan
Ding, Yi
Ke, Chaofu
Handgrip strength is associated with risks of new-onset stroke and heart disease: results from 3 prospective cohorts
title Handgrip strength is associated with risks of new-onset stroke and heart disease: results from 3 prospective cohorts
title_full Handgrip strength is associated with risks of new-onset stroke and heart disease: results from 3 prospective cohorts
title_fullStr Handgrip strength is associated with risks of new-onset stroke and heart disease: results from 3 prospective cohorts
title_full_unstemmed Handgrip strength is associated with risks of new-onset stroke and heart disease: results from 3 prospective cohorts
title_short Handgrip strength is associated with risks of new-onset stroke and heart disease: results from 3 prospective cohorts
title_sort handgrip strength is associated with risks of new-onset stroke and heart disease: results from 3 prospective cohorts
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10161641/
https://www.ncbi.nlm.nih.gov/pubmed/37142986
http://dx.doi.org/10.1186/s12877-023-03953-8
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